(data stored in ACNUC7421 zone)

SWISSPROT: C5BBD0_EDWI9

ID   C5BBD0_EDWI9            Unreviewed;       317 AA.
AC   C5BBD0;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   05-JUL-2017, entry version 68.
DE   RecName: Full=Porphobilinogen deaminase {ECO:0000256|HAMAP-Rule:MF_00260};
DE            Short=PBG {ECO:0000256|HAMAP-Rule:MF_00260};
DE            EC=2.5.1.61 {ECO:0000256|HAMAP-Rule:MF_00260};
DE   AltName: Full=Hydroxymethylbilane synthase {ECO:0000256|HAMAP-Rule:MF_00260};
DE            Short=HMBS {ECO:0000256|HAMAP-Rule:MF_00260};
DE   AltName: Full=Pre-uroporphyrinogen synthase {ECO:0000256|HAMAP-Rule:MF_00260};
GN   Name=hemC {ECO:0000256|HAMAP-Rule:MF_00260};
GN   OrderedLocusNames=NT01EI_0110 {ECO:0000313|EMBL:ACR67365.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67365.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tetrapolymerization of the monopyrrole PBG into the
CC       hydroxymethylbilane pre-uroporphyrinogen in several discrete
CC       steps. {ECO:0000256|HAMAP-Rule:MF_00260,
CC       ECO:0000256|SAAS:SAAS00347445}.
CC   -!- CATALYTIC ACTIVITY: 4 porphobilinogen + H(2)O =
CC       hydroxymethylbilane + 4 NH(3). {ECO:0000256|HAMAP-Rule:MF_00260,
CC       ECO:0000256|SAAS:SAAS00347467}.
CC   -!- COFACTOR:
CC       Name=dipyrromethane; Xref=ChEBI:CHEBI:60342;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00260};
CC       Note=Binds 1 dipyrromethane group covalently. {ECO:0000256|HAMAP-
CC       Rule:MF_00260};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-
CC       IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate:
CC       step 2/4. {ECO:0000256|HAMAP-Rule:MF_00260,
CC       ECO:0000256|SAAS:SAAS00635075}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00260}.
CC   -!- MISCELLANEOUS: The porphobilinogen subunits are added to the
CC       dipyrromethane group. {ECO:0000256|HAMAP-Rule:MF_00260}.
CC   -!- SIMILARITY: Belongs to the HMBS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00260, ECO:0000256|SAAS:SAAS00542451}.
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DR   EMBL; CP001600; ACR67365.1; -; Genomic_DNA.
DR   RefSeq; WP_015869584.1; NC_012779.2.
DR   STRING; 634503.NT01EI_0110; -.
DR   EnsemblBacteria; ACR67365; ACR67365; NT01EI_0110.
DR   GeneID; 7959824; -.
DR   KEGG; eic:NT01EI_0110; -.
DR   PATRIC; fig|634503.3.peg.99; -.
DR   eggNOG; ENOG4105D6W; Bacteria.
DR   eggNOG; COG0181; LUCA.
DR   HOGENOM; HOG000228588; -.
DR   KO; K01749; -.
DR   OMA; CQVPIGV; -.
DR   OrthoDB; POG091H064B; -.
DR   UniPathway; UPA00251; UER00319.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.160.40; -; 1.
DR   HAMAP; MF_00260; Porphobil_deam; 1.
DR   InterPro; IPR000860; HemC.
DR   InterPro; IPR022419; Porphobilin_deaminase_cofac_BS.
DR   InterPro; IPR022417; Porphobilin_deaminase_N.
DR   InterPro; IPR022418; Porphobilinogen_deaminase_C.
DR   PANTHER; PTHR11557; PTHR11557; 1.
DR   Pfam; PF01379; Porphobil_deam; 1.
DR   Pfam; PF03900; Porphobil_deamC; 1.
DR   PIRSF; PIRSF001438; 4pyrrol_synth_OHMeBilane_synth; 1.
DR   PRINTS; PR00151; PORPHBDMNASE.
DR   SUPFAM; SSF54782; SSF54782; 1.
DR   TIGRFAMs; TIGR00212; hemC; 1.
DR   PROSITE; PS00533; PORPHOBILINOGEN_DEAM; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BBD0.
DR   SWISS-2DPAGE; C5BBD0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   Porphyrin biosynthesis {ECO:0000256|HAMAP-Rule:MF_00260,
KW   ECO:0000256|SAAS:SAAS00018392};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00260,
KW   ECO:0000256|SAAS:SAAS00018489, ECO:0000313|EMBL:ACR67365.1}.
FT   DOMAIN       12    218       Porphobil_deam. {ECO:0000259|Pfam:
FT                                PF01379}.
FT   DOMAIN      232    301       Porphobil_deamC. {ECO:0000259|Pfam:
FT                                PF03900}.
FT   MOD_RES     248    248       S-(dipyrrolylmethanemethyl)cysteine.
FT                                {ECO:0000256|HAMAP-Rule:MF_00260}.
SQ   SEQUENCE   317 AA;  34234 MW;  8DCE2FB1A63261BE CRC64;
     MQSMTTATQP TLRIATRQSP LALWQAHYVR DQLLAQWPQL TIELVPMVTR GDVLLDTPLA
     KVGGKGLFVK ELELALLEGR ADIAVHSMKD VPVAFPDGLG LVTICQREDP RDAFVSPRFA
     SLEQLPPGSV VGTSSLRRQC QLRAARPDLQ IRDLRGNVGT RLAKLDAGDY DAIILAAAGL
     KRLQLEDRIR TPLTPEQSLP AVGQGAVGIE CRLADDATRR LLAPLNHAET ALRVCAERAM
     NTRLEGGCQV PIGSYAEIDG DRLWLRALVG APDGSLMICG ERRGPLAQAE AMGTALADEL
     LARGARAILD AVYCQKA
//

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