(data stored in ACNUC7421 zone)

SWISSPROT: C5BC97_EDWI9

ID   C5BC97_EDWI9            Unreviewed;       255 AA.
AC   C5BC97;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 53.
DE   RecName: Full=Uridine phosphorylase {ECO:0000256|RuleBase:RU361131};
DE            EC=2.4.2.3 {ECO:0000256|RuleBase:RU361131};
GN   OrderedLocusNames=NT01EI_0133 {ECO:0000313|EMBL:ACR67388.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67388.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible phosphorylytic cleavage of
CC       uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-
CC       phosphate. The produced molecules are then utilized as carbon and
CC       energy sources or in the rescue of pyrimidine bases for nucleotide
CC       synthesis. {ECO:0000256|RuleBase:RU361131}.
CC   -!- CATALYTIC ACTIVITY: Uridine + phosphate = uracil + alpha-D-ribose
CC       1-phosphate. {ECO:0000256|RuleBase:RU361131}.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage
CC       pathway; uracil from uridine (phosphorylase route): step 1/1.
CC       {ECO:0000256|RuleBase:RU361131}.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000256|SAAS:SAAS00675091}.
CC   -!- SIMILARITY: Belongs to the PNP/UDP phosphorylase family.
CC       {ECO:0000256|RuleBase:RU361131, ECO:0000256|SAAS:SAAS00675087}.
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DR   EMBL; CP001600; ACR67388.1; -; Genomic_DNA.
DR   RefSeq; WP_015869607.1; NC_012779.2.
DR   ProteinModelPortal; C5BC97; -.
DR   STRING; 634503.NT01EI_0133; -.
DR   EnsemblBacteria; ACR67388; ACR67388; NT01EI_0133.
DR   GeneID; 7958733; -.
DR   KEGG; eic:NT01EI_0133; -.
DR   PATRIC; fig|634503.3.peg.124; -.
DR   eggNOG; ENOG4108I5U; Bacteria.
DR   eggNOG; COG2820; LUCA.
DR   HOGENOM; HOG000274897; -.
DR   KO; K00757; -.
DR   OMA; MSDVFHL; -.
DR   OrthoDB; POG091H05D0; -.
DR   UniPathway; UPA00574; UER00633.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004850; F:uridine phosphorylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR   GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR018016; Nucleoside_phosphorylase_CS.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR010058; Uridine_phosphorylase.
DR   PANTHER; PTHR43691:SF6; PTHR43691:SF6; 1.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   SUPFAM; SSF53167; SSF53167; 1.
DR   TIGRFAMs; TIGR01718; Uridine-psphlse; 1.
DR   PROSITE; PS01232; PNP_UDP_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BC97.
DR   SWISS-2DPAGE; C5BC97.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU361131,
KW   ECO:0000256|SAAS:SAAS00675086, ECO:0000313|EMBL:ACR67388.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485};
KW   Transferase {ECO:0000256|RuleBase:RU361131,
KW   ECO:0000256|SAAS:SAAS00675084, ECO:0000313|EMBL:ACR67388.1}.
FT   DOMAIN       21    246       PNP_UDP_1. {ECO:0000259|Pfam:PF01048}.
SQ   SEQUENCE   255 AA;  27353 MW;  C4006F66D0E9FCDE CRC64;
     MSKPEVFHLG LAKSDLHGAT LAIVPGDPER VEKIAKLMEN PVKLASHREF TSWRAELDGK
     AIIVCSTGIG GPSTSIAVEE LAQLGVRTFL RVGTTGAIQP HISVGDVLVT TASVRLDGAS
     LHFAPMEFPA VADFACTTAL VDAAHAVGAA THVGITASSD TFYPGQERYD TFSGRVTRRF
     RGSMKEWQEM GVMNFEMESA TLLTMCSSQG LRAGMVAGVI VNRTQQEIPN AETMKQTESH
     AVKIVVDAAR RLLQD
//

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