(data stored in ACNUC7421 zone)

SWISSPROT: UBIE_EDWI9

ID   UBIE_EDWI9              Reviewed;         251 AA.
AC   C5BCA4;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 56.
DE   RecName: Full=Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE {ECO:0000255|HAMAP-Rule:MF_01813};
DE            EC=2.1.1.163 {ECO:0000255|HAMAP-Rule:MF_01813};
DE            EC=2.1.1.201 {ECO:0000255|HAMAP-Rule:MF_01813};
DE   AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase {ECO:0000255|HAMAP-Rule:MF_01813};
DE   AltName: Full=Demethylmenaquinone methyltransferase {ECO:0000255|HAMAP-Rule:MF_01813};
GN   Name=ubiE {ECO:0000255|HAMAP-Rule:MF_01813};
GN   OrderedLocusNames=NT01EI_0140;
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Methyltransferase required for the conversion of
CC       demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion
CC       of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-
CC       polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
CC       {ECO:0000255|HAMAP-Rule:MF_01813}.
CC   -!- CATALYTIC ACTIVITY: A demethylmenaquinol + S-adenosyl-L-methionine
CC       = a menaquinol + S-adenosyl-L-homocysteine. {ECO:0000255|HAMAP-
CC       Rule:MF_01813}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 2-methoxy-6-all-
CC       trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-
CC       methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
CC       {ECO:0000255|HAMAP-Rule:MF_01813}.
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis;
CC       menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.
CC       {ECO:0000255|HAMAP-Rule:MF_01813}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01813}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. MenG/UbiE family.
CC       {ECO:0000255|HAMAP-Rule:MF_01813}.
DR   EMBL; CP001600; ACR67395.1; -; Genomic_DNA.
DR   RefSeq; WP_015869611.1; NC_012779.2.
DR   ProteinModelPortal; C5BCA4; -.
DR   SMR; C5BCA4; -.
DR   STRING; 634503.NT01EI_0140; -.
DR   EnsemblBacteria; ACR67395; ACR67395; NT01EI_0140.
DR   GeneID; 7958740; -.
DR   KEGG; eic:NT01EI_0140; -.
DR   PATRIC; fig|634503.3.peg.131; -.
DR   eggNOG; ENOG4105DDZ; Bacteria.
DR   eggNOG; COG2226; LUCA.
DR   HOGENOM; HOG000249463; -.
DR   KO; K03183; -.
DR   OMA; VRNFENL; -.
DR   OrthoDB; POG091H01LK; -.
DR   UniPathway; UPA00079; UER00169.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0102005; F:2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01813; MenG_UbiE_methyltr; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR   InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR   Pfam; PF01209; Ubie_methyltran; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR   PROSITE; PS51608; SAM_MT_UBIE; 1.
DR   PROSITE; PS01183; UBIE_1; 1.
DR   PROSITE; PS01184; UBIE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BCA4.
DR   SWISS-2DPAGE; C5BCA4.
KW   Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase;
KW   Ubiquinone biosynthesis.
FT   CHAIN         1    251       Ubiquinone/menaquinone biosynthesis C-
FT                                methyltransferase UbiE.
FT                                /FTId=PRO_1000215984.
FT   REGION      123    124       S-adenosyl-L-methionine binding.
FT                                {ECO:0000255|HAMAP-Rule:MF_01813}.
FT   BINDING      74     74       S-adenosyl-L-methionine.
FT                                {ECO:0000255|HAMAP-Rule:MF_01813}.
FT   BINDING      95     95       S-adenosyl-L-methionine.
FT                                {ECO:0000255|HAMAP-Rule:MF_01813}.
SQ   SEQUENCE   251 AA;  27942 MW;  A5E2A21F8FF4C236 CRC64;
     MVDQTPETTH FGYKTVAAAD KAGKVAQVFH SVAGKYDLMN DLMSFGIHRL WKRFTIDCSG
     VRQGQRVLDL AGGTGDLAAR FSRMVGEQGE VILADINDSM LKIGREKLRN MGIVGNLNYV
     QANAEALPFP ENYFDCITIA FGLRNVTDKD KALRSMFRVL KPGGRLLVLE FSRPQFVALS
     KAYDAYSFHI LPRIGEMVAH DGDSYRYLAE SIRMHPDQET LKGMMAAAGF ENTTYDNLTG
     GIVALHRGYK F
//

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