(data stored in ACNUC7421 zone)

SWISSPROT: C5BCB2_EDWI9

ID   C5BCB2_EDWI9            Unreviewed;       163 AA.
AC   C5BCB2;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 54.
DE   RecName: Full=Transcription antitermination protein RfaH {ECO:0000256|HAMAP-Rule:MF_00951};
GN   Name=rfaH {ECO:0000256|HAMAP-Rule:MF_00951};
GN   OrderedLocusNames=NT01EI_0148 {ECO:0000313|EMBL:ACR67403.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67403.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enhances distal genes transcription elongation in a
CC       specialized subset of operons that encode extracytoplasmic
CC       components. RfaH is recruited into a multi-component RNA
CC       polymerase complex by the ops element, which is a short conserved
CC       DNA sequence located downstream of the main promoter of these
CC       operons. Once bound, RfaH suppresses pausing and inhibits Rho-
CC       dependent and intrinsic termination at a subset of sites.
CC       Termination signals are bypassed, which allows complete synthesis
CC       of long RNA chains. {ECO:0000256|HAMAP-Rule:MF_00951}.
CC   -!- SUBUNIT: Interacts with both the nontemplate DNA and the RNA
CC       polymerase (RNAP). {ECO:0000256|HAMAP-Rule:MF_00951}.
CC   -!- SIMILARITY: Belongs to the RfaH family. {ECO:0000256|HAMAP-
CC       Rule:MF_00951}.
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DR   EMBL; CP001600; ACR67403.1; -; Genomic_DNA.
DR   RefSeq; WP_015869619.1; NC_012779.2.
DR   STRING; 634503.NT01EI_0148; -.
DR   EnsemblBacteria; ACR67403; ACR67403; NT01EI_0148.
DR   GeneID; 7958748; -.
DR   KEGG; eic:NT01EI_0148; -.
DR   PATRIC; fig|634503.3.peg.139; -.
DR   eggNOG; ENOG4105MDZ; Bacteria.
DR   eggNOG; COG0250; LUCA.
DR   HOGENOM; HOG000272711; -.
DR   KO; K05785; -.
DR   OMA; NQGVECF; -.
DR   OrthoDB; POG091H04HH; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0001073; F:transcription antitermination factor activity, DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 3.30.70.940; -; 1.
DR   HAMAP; MF_00951; RfaH; 1.
DR   InterPro; IPR006645; NGN_dom.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR010215; Transcription_antiterm_RfaH.
DR   InterPro; IPR008991; Translation_prot_SH3-like.
DR   Pfam; PF02357; NusG; 1.
DR   SMART; SM00738; NGN; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   SUPFAM; SSF82679; SSF82679; 1.
DR   TIGRFAMs; TIGR01955; RfaH; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BCB2.
DR   SWISS-2DPAGE; C5BCB2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00951};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00951};
KW   Transcription antitermination {ECO:0000256|HAMAP-Rule:MF_00951,
KW   ECO:0000256|SAAS:SAAS00454500};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00951}.
FT   DOMAIN        1    100       NGN. {ECO:0000259|SMART:SM00738}.
SQ   SEQUENCE   163 AA;  18592 MW;  793CE6B7A367E24E CRC64;
     MESWYLLYCK RGQLTRAREH LTRQEIPCVI PMITLEKVVR GKRTQVQEPM FPNYMFIELD
     PERIHTTTVQ STRGVSHFIR FGKLPAIVPF SIVKPLMMTP ALTAIAPQTP IPGDRVRITQ
     GAFNGIEAIY RESDGEKRAI LLLSLLNQEV SHTLSNSAFE KIL
//

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