(data stored in ACNUC7421 zone)

SWISSPROT: C5BCC3_EDWI9

ID   C5BCC3_EDWI9            Unreviewed;       315 AA.
AC   C5BCC3;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   30-AUG-2017, entry version 64.
DE   RecName: Full=Pantothenate kinase {ECO:0000256|HAMAP-Rule:MF_00215, ECO:0000256|RuleBase:RU003530, ECO:0000256|SAAS:SAAS00765426};
DE            EC=2.7.1.33 {ECO:0000256|HAMAP-Rule:MF_00215, ECO:0000256|RuleBase:RU003530, ECO:0000256|SAAS:SAAS00765418};
DE   AltName: Full=Pantothenic acid kinase {ECO:0000256|HAMAP-Rule:MF_00215};
GN   Name=coaA {ECO:0000256|HAMAP-Rule:MF_00215};
GN   OrderedLocusNames=NT01EI_0162 {ECO:0000313|EMBL:ACR67414.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67414.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'-
CC       phosphopantothenate. {ECO:0000256|HAMAP-Rule:MF_00215,
CC       ECO:0000256|RuleBase:RU003530, ECO:0000256|SAAS:SAAS00765420}.
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from
CC       (R)-pantothenate: step 1/5. {ECO:0000256|HAMAP-Rule:MF_00215,
CC       ECO:0000256|RuleBase:RU003530, ECO:0000256|SAAS:SAAS00765445}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00215,
CC       ECO:0000256|RuleBase:RU003530, ECO:0000256|SAAS:SAAS00765478}.
CC   -!- SIMILARITY: Belongs to the prokaryotic pantothenate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00215, ECO:0000256|RuleBase:RU003530,
CC       ECO:0000256|SAAS:SAAS00765429}.
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DR   EMBL; CP001600; ACR67414.1; -; Genomic_DNA.
DR   RefSeq; WP_015869629.1; NC_012779.2.
DR   STRING; 634503.NT01EI_0162; -.
DR   EnsemblBacteria; ACR67414; ACR67414; NT01EI_0162.
DR   GeneID; 7958759; -.
DR   KEGG; eic:NT01EI_0162; -.
DR   PATRIC; fig|634503.3.peg.149; -.
DR   eggNOG; ENOG4105CS9; Bacteria.
DR   eggNOG; COG1072; LUCA.
DR   HOGENOM; HOG000248571; -.
DR   KO; K00867; -.
DR   OMA; LMQRKGF; -.
DR   OrthoDB; POG091H073G; -.
DR   UniPathway; UPA00241; UER00352.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004594; F:pantothenate kinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-HAMAP.
DR   CDD; cd02025; PanK; 1.
DR   HAMAP; MF_00215; Pantothen_kinase_1; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004566; PanK.
DR   InterPro; IPR006083; PRK/URK.
DR   PANTHER; PTHR10285:SF85; PTHR10285:SF85; 1.
DR   Pfam; PF00485; PRK; 1.
DR   PIRSF; PIRSF000545; Pantothenate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00554; panK_bact; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BCC3.
DR   SWISS-2DPAGE; C5BCC3.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00215,
KW   ECO:0000256|SAAS:SAAS00768779};
KW   Coenzyme A biosynthesis {ECO:0000256|HAMAP-Rule:MF_00215,
KW   ECO:0000256|RuleBase:RU003530, ECO:0000256|SAAS:SAAS00765455};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00215,
KW   ECO:0000256|RuleBase:RU003530, ECO:0000256|SAAS:SAAS00765414};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00215,
KW   ECO:0000256|SAAS:SAAS00768783, ECO:0000313|EMBL:ACR67414.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00215,
KW   ECO:0000256|SAAS:SAAS00768775};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00215,
KW   ECO:0000256|SAAS:SAAS00768777, ECO:0000313|EMBL:ACR67414.1}.
FT   DOMAIN       89    242       PRK. {ECO:0000259|Pfam:PF00485}.
FT   NP_BIND      94    101       ATP. {ECO:0000256|HAMAP-Rule:MF_00215}.
SQ   SEQUENCE   315 AA;  36093 MW;  B00F1A401956E167 CRC64;
     MKKEQSLATP YLQFDRHQWA ALRNSVPLTL TEEEIARLKG INEDLSLDEV AQIYLPLSRL
     LNFYFSSSVS RQVVLEKFLG THSPRIPYII GIAGSVAVGK STTARVLQAL LSRWPEHRRV
     ELITTDGFLH PNKILQERGL MKKKGFPQSY DMHHLVKFVS DIKSGVSQVT APQYSHLIYD
     VLPDSRKLIE QPDILILEGL NVLQSGMDYP HDPHRVFVSD FVDFSIYVDA DEHQLQAWYI
     NRFLKFREGA FSNPDSYFHH YSQLPESEAI AIATGLWNEI NGLNLRQNIL PTRERASLIM
     TKGSNHAIES VRLRK
//

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