(data stored in ACNUC7421 zone)

SWISSPROT: C5B6Y4_EDWI9

ID   C5B6Y4_EDWI9            Unreviewed;       760 AA.
AC   C5B6Y4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   30-AUG-2017, entry version 57.
DE   RecName: Full=DNA topoisomerase 4 subunit A {ECO:0000256|HAMAP-Rule:MF_00936};
DE            EC=5.99.1.3 {ECO:0000256|HAMAP-Rule:MF_00936};
DE   AltName: Full=Topoisomerase IV subunit A {ECO:0000256|HAMAP-Rule:MF_00936};
GN   Name=parC {ECO:0000256|HAMAP-Rule:MF_00936};
GN   OrderedLocusNames=NT01EI_0203 {ECO:0000313|EMBL:ACR67446.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67446.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Topoisomerase IV is essential for chromosome
CC       segregation. It relaxes supercoiled DNA. Performs the decatenation
CC       events required during the replication of a circular DNA molecule.
CC       {ECO:0000256|HAMAP-Rule:MF_00936}.
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA. {ECO:0000256|HAMAP-Rule:MF_00936,
CC       ECO:0000256|SAAS:SAAS00846455}.
CC   -!- SUBUNIT: Heterotetramer composed of ParC and ParE.
CC       {ECO:0000256|HAMAP-Rule:MF_00936}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
CC       Rule:MF_00936}; Peripheral membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_00936}.
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. ParC type 1 subfamily. {ECO:0000256|HAMAP-Rule:MF_00936}.
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DR   EMBL; CP001600; ACR67446.1; -; Genomic_DNA.
DR   RefSeq; WP_015869657.1; NC_012779.2.
DR   STRING; 634503.NT01EI_0203; -.
DR   EnsemblBacteria; ACR67446; ACR67446; NT01EI_0203.
DR   GeneID; 7958791; -.
DR   KEGG; eic:NT01EI_0203; -.
DR   PATRIC; fig|634503.3.peg.180; -.
DR   eggNOG; ENOG4105C24; Bacteria.
DR   eggNOG; COG0188; LUCA.
DR   HOGENOM; HOG000076277; -.
DR   KO; K02621; -.
DR   OMA; GYGFICT; -.
DR   OrthoDB; POG091H025U; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0019897; C:extrinsic component of plasma membrane; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003918; F:DNA topoisomerase type II (ATP-hydrolyzing) activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006265; P:DNA topological change; IEA:UniProtKB-HAMAP.
DR   Gene3D; 1.10.268.10; -; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 3.90.199.10; -; 1.
DR   HAMAP; MF_00936; ParC_type1; 1.
DR   InterPro; IPR024946; Arg_repress_C-like.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR005742; TopoIV_A_Gneg.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; SSF101904; 1.
DR   SUPFAM; SSF56719; SSF56719; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5B6Y4.
DR   SWISS-2DPAGE; C5B6Y4.
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00936};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00936,
KW   ECO:0000256|SAAS:SAAS00846460};
KW   Isomerase {ECO:0000256|HAMAP-Rule:MF_00936,
KW   ECO:0000256|SAAS:SAAS00846445, ECO:0000313|EMBL:ACR67446.1};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_00936};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485};
KW   Topoisomerase {ECO:0000256|HAMAP-Rule:MF_00936,
KW   ECO:0000256|SAAS:SAAS00846490}.
FT   DOMAIN       12    462       TOP4c. {ECO:0000259|SMART:SM00434}.
FT   ACT_SITE    124    124       O-(5'-phospho-DNA)-tyrosine intermediate.
FT                                {ECO:0000256|HAMAP-Rule:MF_00936}.
FT   SITE         43     43       Interaction with DNA. {ECO:0000256|HAMAP-
FT                                Rule:MF_00936}.
FT   SITE         79     79       Interaction with DNA. {ECO:0000256|HAMAP-
FT                                Rule:MF_00936}.
FT   SITE         81     81       Interaction with DNA. {ECO:0000256|HAMAP-
FT                                Rule:MF_00936}.
FT   SITE        123    123       Transition state stabilizer.
FT                                {ECO:0000256|HAMAP-Rule:MF_00936}.
SQ   SEQUENCE   760 AA;  84464 MW;  5F0C8EEF33E95C9A CRC64;
     MSDLTHDNSE RVALHAFTED AYLQYSMYVI MDRALPFIGD GLKPVQRRIV YAMSELGLSA
     SAKFKKSART VGDVLGKYHP HGDSACYEAM VLMAQPFSYR YPLVDGQGNW GAPDDPKSFA
     AMRYTESRLS RYAEILLSEL GQGTVDYVAN FDGTLQEPKF LPARLPNILL NGTTGIAVGM
     ATDIPPHNAR EVAAALVALL DNPQSSLDDL LTHIQGPDFP TEAEIITPRD EIHKIYRTGR
     GSVRMRAVWR KEEGEIVISA LPHQTSGAKV LEQIASQMRA KKLPMVDDLR DESDHENPTR
     LVIVPRSNRV DLDQLMNHLF ATTDLEKSYR INMNMIGLDR RPAVKDLREI LSEWLSYRRE
     TVRRRLNYRL EKVLKRLHIL DGLLCAFLNI DEVIHIIRSE DEPKPVLVAR FGLSDTQAEA
     ILELKLRHLA RLEEVKIRGE QDELAQERDR LQTLLASERK LGTLIKKEIM ADAETYGDAR
     RSPLQERSEA RAMSEHDFVP NEPVTIVLSE GGWVRSAKGH DIDPSGLNYK AGDAFRAAAR
     GKSNQPVVFI DSSGRSYALD PLTLPSARGQ GEPLTGKLTP PPGATIEHVL MAADDQKLLM
     ASDAGYGFVC TFSDLVARNR AGKAMLTLPE NANVLTPLEI NGDDDMLLAI TEAGRMLMFP
     VHDLPQLSKG KGNKIVSIPA AQAAAGEDTL KWLLVLAPQT SLTLHIGKRK LVMKPQDLQK
     FRAERGRKGT LLPRGLQRIE RVDVDAPLSL RLDADAEGDA
//

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