(data stored in ACNUC7421 zone)

SWISSPROT: NIKR_EDWI9

ID   NIKR_EDWI9              Reviewed;         145 AA.
AC   C5BCE8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   05-JUL-2017, entry version 55.
DE   RecName: Full=Nickel-responsive regulator {ECO:0000255|HAMAP-Rule:MF_00476};
GN   Name=nikR {ECO:0000255|HAMAP-Rule:MF_00476};
GN   OrderedLocusNames=NT01EI_0269;
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor of the nikABCDE operon. Is
CC       active in the presence of excessive concentrations of
CC       intracellular nickel. {ECO:0000255|HAMAP-Rule:MF_00476}.
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00476};
CC       Note=Binds 1 nickel ion per subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_00476};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00476}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR
CC       family. {ECO:0000255|HAMAP-Rule:MF_00476}.
DR   EMBL; CP001600; ACR67511.1; -; Genomic_DNA.
DR   ProteinModelPortal; C5BCE8; -.
DR   SMR; C5BCE8; -.
DR   STRING; 634503.NT01EI_0269; -.
DR   EnsemblBacteria; ACR67511; ACR67511; NT01EI_0269.
DR   KEGG; eic:NT01EI_0269; -.
DR   eggNOG; ENOG4105MRR; Bacteria.
DR   eggNOG; COG0864; LUCA.
DR   HOGENOM; HOG000102781; -.
DR   KO; K07722; -.
DR   OMA; HLDHDNC; -.
DR   OrthoDB; POG091H0IEB; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0010045; P:response to nickel cation; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   HAMAP; MF_00476; NikR; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR002145; CopG.
DR   InterPro; IPR022988; Ni_resp_reg_NikR.
DR   InterPro; IPR014160; Nickel_NikR_proteobac.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   InterPro; IPR014864; TF_NikR_Ni-bd_C.
DR   Pfam; PF08753; NikR_C; 1.
DR   Pfam; PF01402; RHH_1; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
DR   TIGRFAMs; TIGR02793; nikR; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BCE8.
DR   SWISS-2DPAGE; C5BCE8.
KW   Complete proteome; DNA-binding; Metal-binding; Nickel;
KW   Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    145       Nickel-responsive regulator.
FT                                /FTId=PRO_1000206379.
FT   METAL        77     77       Nickel. {ECO:0000255|HAMAP-
FT                                Rule:MF_00476}.
FT   METAL        88     88       Nickel. {ECO:0000255|HAMAP-
FT                                Rule:MF_00476}.
FT   METAL        90     90       Nickel. {ECO:0000255|HAMAP-
FT                                Rule:MF_00476}.
FT   METAL        96     96       Nickel. {ECO:0000255|HAMAP-
FT                                Rule:MF_00476}.
SQ   SEQUENCE   145 AA;  15922 MW;  952C050BBAA29335 CRC64;
     MQRVTLSLDD DLMAEIDAII RAGNYQNRSE VIRDLARAGL QSMAQAPSPS ACCVAALFYV
     YDHESRELSK RLTRTFHDHH DLSLASLHVH LDHGSCLEVS LLKGAGGEVT RFAERVIAER
     GVRHGKLVVV PGDEGVAPPH PHSHD
//

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