(data stored in ACNUC7421 zone)

SWISSPROT: C5BDK2_EDWI9

ID   C5BDK2_EDWI9            Unreviewed;       478 AA.
AC   C5BDK2;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 55.
DE   RecName: Full=Aspartate ammonia-lyase {ECO:0000256|RuleBase:RU362017};
DE            Short=Aspartase {ECO:0000256|RuleBase:RU362017};
DE            EC=4.3.1.1 {ECO:0000256|RuleBase:RU362017};
GN   OrderedLocusNames=NT01EI_0377 {ECO:0000313|EMBL:ACR67618.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67618.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACR67618.1, ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|EMBL:ACR67618.1,
RC   ECO:0000313|Proteomes:UP000001485};
RX   PubMed=22247535; DOI=10.1128/JB.06522-11;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Banes M.M.,
RA   Lawrence M.L.;
RT   "Genome Sequence of Edwardsiella ictaluri 93-146, a Strain Associated
RT   with a Natural Channel Catfish Outbreak of Enteric Septicemia of
RT   Catfish.";
RL   J. Bacteriol. 194:740-741(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-aspartate = fumarate + NH4(+); Xref=Rhea:RHEA:16601,
CC         ChEBI:CHEBI:28938, ChEBI:CHEBI:29806, ChEBI:CHEBI:29991;
CC         EC=4.3.1.1; Evidence={ECO:0000256|RuleBase:RU362017};
CC   -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family.
CC       Aspartase subfamily. {ECO:0000256|RuleBase:RU362017}.
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DR   EMBL; CP001600; ACR67618.1; -; Genomic_DNA.
DR   RefSeq; WP_015869824.1; NC_012779.2.
DR   EnsemblBacteria; ACR67618; ACR67618; NT01EI_0377.
DR   GeneID; 7960157; -.
DR   KEGG; eic:NT01EI_0377; -.
DR   PATRIC; fig|634503.3.peg.341; -.
DR   eggNOG; ENOG4108IJ0; Bacteria.
DR   eggNOG; COG1027; LUCA.
DR   HOGENOM; HOG000061737; -.
DR   KO; K01744; -.
DR   OMA; EICENYV; -.
DR   OrthoDB; 734949at2; -.
DR   BioCyc; EICT634503:G1GVC-351-MONOMER; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0008797; F:aspartate ammonia-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006531; P:aspartate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   Gene3D; 1.10.275.10; -; 1.
DR   InterPro; IPR004708; ApsA.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR018951; Fumarase_C_C.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   Pfam; PF10415; FumaraseC_C; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00839; aspA; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BDK2.
DR   SWISS-2DPAGE; C5BDK2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   Lyase {ECO:0000256|RuleBase:RU362017, ECO:0000256|SAAS:SAAS00674282,
KW   ECO:0000313|EMBL:ACR67618.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485}.
FT   DOMAIN       13    345       Lyase_1. {ECO:0000259|Pfam:PF00206}.
FT   DOMAIN      411    464       FumaraseC_C. {ECO:0000259|Pfam:PF10415}.
SQ   SEQUENCE   478 AA;  52488 MW;  16FFD5049BAB27CD CRC64;
     MSNNIRIEED LLGTREVPAD AYYGVHTLRA MENFYISNNK ISDIPEFVRG MVMVKKAAAL
     ANRELQTIPR KIADTIILAC DEVLNNGKCM DQFPVDVFQG GAGTSVNMNT NEVLANIGLE
     LLGHKKGEYQ YLNPNDHLNK CQSTNDAYPT GFRIAVYASI MKLIEAVKNL REGVDRKADE
     FKNILKMGRT QLQDAVPMTL GQEFHAFSVL LNEEVKNLQR TAELLLEINL GATAIGTGLN
     TPEGYQKLAV QKLAEVSGLP CVPAEDLIEA TSDCGSYVMV HSALKRTAVK LSKICNDLRL
     LSSGPRAGLN EINLPELQAG SSIMPAKVNP VVPEVVNQLC FKVIGNDTCV TMAAEAGQLQ
     LNVMEPVIGQ AMFESISLLT NGCYNLREKC IDGITANKEI CEKFVFNSIG IVTYLNPFIG
     HHNGDIVGKI CAETGKSVRE VVLERGLLTE AQLDDIFSVE NLMHPAYKAK RYTDESEK
//

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