(data stored in ACNUC7421 zone)

SWISSPROT: C5B775_EDWI9

ID   C5B775_EDWI9            Unreviewed;       110 AA.
AC   C5B775;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 62.
DE   RecName: Full=Trp operon repressor {ECO:0000256|HAMAP-Rule:MF_00475, ECO:0000256|SAAS:SAAS00826617};
GN   Name=trpR {ECO:0000256|HAMAP-Rule:MF_00475};
GN   OrderedLocusNames=NT01EI_0623 {ECO:0000313|EMBL:ACR67850.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67850.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is an aporepressor. When complexed with L-
CC       tryptophan it binds the operator region of the trp operon (5'-
CC       ACTAGT-'3') and prevents the initiation of transcription. The
CC       complex also regulates trp repressor biosynthesis by binding to
CC       its regulatory region. {ECO:0000256|HAMAP-Rule:MF_00475,
CC       ECO:0000256|SAAS:SAAS00826616}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00475,
CC       ECO:0000256|SAAS:SAAS00697682}.
CC   -!- SIMILARITY: Belongs to the TrpR family. {ECO:0000256|HAMAP-
CC       Rule:MF_00475, ECO:0000256|SAAS:SAAS00697680}.
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DR   EMBL; CP001600; ACR67850.1; -; Genomic_DNA.
DR   RefSeq; WP_015870046.1; NC_012779.2.
DR   STRING; 634503.NT01EI_0623; -.
DR   EnsemblBacteria; ACR67850; ACR67850; NT01EI_0623.
DR   GeneID; 7960388; -.
DR   KEGG; eic:NT01EI_0623; -.
DR   PATRIC; fig|634503.3.peg.564; -.
DR   eggNOG; ENOG4105R9M; Bacteria.
DR   eggNOG; COG2973; LUCA.
DR   HOGENOM; HOG000288846; -.
DR   KO; K03720; -.
DR   OMA; MMTPDER; -.
DR   OrthoDB; POG091H05S6; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   HAMAP; MF_00475; Trp_repressor; 1.
DR   InterPro; IPR000831; Trp_repress.
DR   InterPro; IPR013335; Trp_repress_bac.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR38025:SF2; PTHR38025:SF2; 1.
DR   Pfam; PF01371; Trp_repressor; 1.
DR   PIRSF; PIRSF003196; Trp_repressor; 1.
DR   ProDom; PD012582; Trp_repress_bac; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   TIGRFAMs; TIGR01321; TrpR; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5B775.
DR   SWISS-2DPAGE; C5B775.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00475,
KW   ECO:0000256|SAAS:SAAS00697683};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00475,
KW   ECO:0000256|SAAS:SAAS00697687};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485};
KW   Repressor {ECO:0000256|HAMAP-Rule:MF_00475,
KW   ECO:0000256|SAAS:SAAS00697689};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00475,
KW   ECO:0000256|SAAS:SAAS00697690};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00475,
KW   ECO:0000256|SAAS:SAAS00697686}.
FT   DNA_BIND     67     90       {ECO:0000256|HAMAP-Rule:MF_00475}.
SQ   SEQUENCE   110 AA;  12522 MW;  59B1C70125B064DD CRC64;
     MQKTTPTPDQ VSAEPDDWQR FIQLLQQAYQ EGRQEPMLQL FLTPDERDAL ATRVRIIEEL
     LKGEMSQREL KSQLGAGIAT ITRGSNSLKM ASPDFKQWLV RQLLPATPQA
//

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