(data stored in ACNUC7421 zone)

SWISSPROT: KHSE_EDWI9

ID   KHSE_EDWI9              Reviewed;         309 AA.
AC   C5B7K5;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 51.
DE   RecName: Full=Homoserine kinase {ECO:0000255|HAMAP-Rule:MF_00384};
DE            Short=HK {ECO:0000255|HAMAP-Rule:MF_00384};
DE            Short=HSK {ECO:0000255|HAMAP-Rule:MF_00384};
DE            EC=2.7.1.39 {ECO:0000255|HAMAP-Rule:MF_00384};
GN   Name=thrB {ECO:0000255|HAMAP-Rule:MF_00384};
GN   OrderedLocusNames=NT01EI_0660;
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the ATP-dependent phosphorylation of L-
CC       homoserine to L-homoserine phosphate. {ECO:0000255|HAMAP-
CC       Rule:MF_00384}.
CC   -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC       homoserine. {ECO:0000255|HAMAP-Rule:MF_00384}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00384}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Homoserine kinase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00384}.
DR   EMBL; CP001600; ACR67882.1; -; Genomic_DNA.
DR   RefSeq; WP_015870076.1; NC_012779.2.
DR   ProteinModelPortal; C5B7K5; -.
DR   SMR; C5B7K5; -.
DR   STRING; 634503.NT01EI_0660; -.
DR   EnsemblBacteria; ACR67882; ACR67882; NT01EI_0660.
DR   GeneID; 7961994; -.
DR   KEGG; eic:NT01EI_0660; -.
DR   PATRIC; fig|634503.3.peg.594; -.
DR   eggNOG; ENOG4105D5I; Bacteria.
DR   eggNOG; COG0083; LUCA.
DR   HOGENOM; HOG000247198; -.
DR   KO; K00872; -.
DR   OMA; PDNVAPC; -.
DR   OrthoDB; POG091H020X; -.
DR   UniPathway; UPA00050; UER00064.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.890; -; 1.
DR   HAMAP; MF_00384; Homoser_kinase; 1.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR   InterPro; IPR000870; Homoserine_kinase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000676; Homoser_kin; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55060; SSF55060; 1.
DR   TIGRFAMs; TIGR00191; thrB; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5B7K5.
DR   SWISS-2DPAGE; C5B7K5.
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Reference proteome;
KW   Threonine biosynthesis; Transferase.
FT   CHAIN         1    309       Homoserine kinase.
FT                                /FTId=PRO_1000205734.
FT   NP_BIND      91    101       ATP. {ECO:0000255|HAMAP-Rule:MF_00384}.
SQ   SEQUENCE   309 AA;  32958 MW;  A10D378B74D1EA04 CRC64;
     MVKIYAPASI GNVSIGFDVL GAAVTPLDGT LLGDCVSIAA SSHFSLHCHG RFVDSLPSTV
     QENIVYQCWQ RFCEVTGREL AVEMVLEKNM PIGSGLGSSA CSVVAALAAL NRFAGEPLDA
     HRLLMLMGEL EGRISGSVHY DNVAPCYLGG LQLMLEAQEI ISQPVPCFDE WLWVMAYPGI
     KVSTAEARAI LPPHYSRGDC VRHGRHLAGF IHACHTRQPS LAAALMQDVI AEPYRCGLLP
     GFADARRAAG ELGALACGIS GSGPTLFAVC DDLTAAQAVA QWLAQHYLQN EQGFVHICRL
     DSAGARQLG
//

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