(data stored in ACNUC7421 zone)

SWISSPROT: NHAA_EDWI9

ID   NHAA_EDWI9              Reviewed;         392 AA.
AC   C5B7L9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 49.
DE   RecName: Full=Na(+)/H(+) antiporter NhaA {ECO:0000255|HAMAP-Rule:MF_01844};
DE   AltName: Full=Sodium/proton antiporter NhaA {ECO:0000255|HAMAP-Rule:MF_01844};
GN   Name=nhaA {ECO:0000255|HAMAP-Rule:MF_01844};
GN   OrderedLocusNames=NT01EI_0674;
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000255|HAMAP-Rule:MF_01844}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01844}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01844}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000255|HAMAP-Rule:MF_01844}.
DR   EMBL; CP001600; ACR67896.1; -; Genomic_DNA.
DR   RefSeq; WP_015870090.1; NC_012779.2.
DR   SMR; C5B7L9; -.
DR   STRING; 634503.NT01EI_0674; -.
DR   EnsemblBacteria; ACR67896; ACR67896; NT01EI_0674.
DR   GeneID; 7962008; -.
DR   KEGG; eic:NT01EI_0674; -.
DR   PATRIC; fig|634503.3.peg.607; -.
DR   eggNOG; ENOG4105DRC; Bacteria.
DR   eggNOG; COG3004; LUCA.
DR   HOGENOM; HOG000218489; -.
DR   KO; K03313; -.
DR   OMA; LTWTHIT; -.
DR   OrthoDB; POG091H05CU; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   HAMAP; MF_01844; NhaA; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom.
DR   InterPro; IPR004670; NhaA.
DR   PANTHER; PTHR30341:SF2; PTHR30341:SF2; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   TIGRFAMs; TIGR00773; NhaA; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5B7L9.
DR   SWISS-2DPAGE; C5B7L9.
KW   Antiport; Cell inner membrane; Cell membrane; Complete proteome;
KW   Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    392       Na(+)/H(+) antiporter NhaA.
FT                                /FTId=PRO_1000216102.
FT   TRANSMEM      8     28       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM     60     80       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM     96    116       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    126    146       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    155    175       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    181    201       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    206    226       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    255    275       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    279    299       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    329    349       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    360    380       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
SQ   SEQUENCE   392 AA;  41120 MW;  2DF8E70F59783C0D CRC64;
     MIKSLQRFVG SDAFGGVILI IAAALAMILA NTDWTSHIYQ AFLNTPVEVH VGSLHINKNM
     LLWVNDALMA VFFLMIGLEV KRELVCGSLA SARQAAFPVI AAVGGMVVPA LIYLLFNGQD
     AVASTGWAIP AATDIAFALG VLALLGNRVP LALKVFLLAL AIIDDLGAII IIALFYTSDL
     SILSLAVAGA AIVALALLNL FNVRRVGLYI LVGVVLWTAV LKSGVHATLA GVVIGFFVPL
     KEQDGKSPAR SLEHALHPWV AYMILPLFAF ANAGVSLDGV TLSGLFSLLP LGVIAGLFIG
     KPLGISLFCW LAVKLKLATL PQGTTFKEII AIGVLCGIGF TMSIFIASLA FGDADPALAV
     FSRLGILLGS SLAAIVGYLL LRRVLPVQKA VA
//

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