(data stored in ACNUC7421 zone)

SWISSPROT: LEUD_EDWI9

ID   LEUD_EDWI9              Reviewed;         200 AA.
AC   C5B7R1;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 50.
DE   RecName: Full=3-isopropylmalate dehydratase small subunit {ECO:0000255|HAMAP-Rule:MF_01031};
DE            EC=4.2.1.33 {ECO:0000255|HAMAP-Rule:MF_01031};
DE   AltName: Full=Alpha-IPM isomerase {ECO:0000255|HAMAP-Rule:MF_01031};
DE            Short=IPMI {ECO:0000255|HAMAP-Rule:MF_01031};
DE   AltName: Full=Isopropylmalate isomerase {ECO:0000255|HAMAP-Rule:MF_01031};
GN   Name=leuD {ECO:0000255|HAMAP-Rule:MF_01031};
GN   OrderedLocusNames=NT01EI_0717;
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the isomerization between 2-isopropylmalate
CC       and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
CC       {ECO:0000255|HAMAP-Rule:MF_01031}.
CC   -!- CATALYTIC ACTIVITY: (2R,3S)-3-isopropylmalate = (2S)-2-
CC       isopropylmalate. {ECO:0000255|HAMAP-Rule:MF_01031}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-
CC       leucine from 3-methyl-2-oxobutanoate: step 2/4.
CC       {ECO:0000255|HAMAP-Rule:MF_01031}.
CC   -!- SUBUNIT: Heterodimer of LeuC and LeuD. {ECO:0000255|HAMAP-
CC       Rule:MF_01031}.
CC   -!- SIMILARITY: Belongs to the LeuD family. LeuD type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01031}.
DR   EMBL; CP001600; ACR67938.1; -; Genomic_DNA.
DR   RefSeq; WP_015870131.1; NC_012779.2.
DR   ProteinModelPortal; C5B7R1; -.
DR   SMR; C5B7R1; -.
DR   STRING; 634503.NT01EI_0717; -.
DR   PRIDE; C5B7R1; -.
DR   EnsemblBacteria; ACR67938; ACR67938; NT01EI_0717.
DR   GeneID; 7962050; -.
DR   KEGG; eic:NT01EI_0717; -.
DR   PATRIC; fig|634503.3.peg.646; -.
DR   eggNOG; ENOG4105MQS; Bacteria.
DR   eggNOG; COG0066; LUCA.
DR   HOGENOM; HOG000222939; -.
DR   KO; K01704; -.
DR   OMA; AFTTHTG; -.
DR   OrthoDB; POG091H02FJ; -.
DR   UniPathway; UPA00048; UER00071.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0009316; C:3-isopropylmalate dehydratase complex; IEA:InterPro.
DR   GO; GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd01577; IPMI_Swivel; 1.
DR   Gene3D; 3.20.19.10; -; 1.
DR   HAMAP; MF_01031; LeuD_type1; 1.
DR   InterPro; IPR004431; 3-IsopropMal_deHydase_ssu.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   InterPro; IPR033940; IPMI_Swivel.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   SUPFAM; SSF52016; SSF52016; 1.
DR   TIGRFAMs; TIGR00171; leuD; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5B7R1.
DR   SWISS-2DPAGE; C5B7R1.
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; Leucine biosynthesis; Lyase; Reference proteome.
FT   CHAIN         1    200       3-isopropylmalate dehydratase small
FT                                subunit.
FT                                /FTId=PRO_1000213350.
SQ   SEQUENCE   200 AA;  22348 MW;  A595E4E90E256232 CRC64;
     MTEFTRHTGI VVPLDAANVD TDAIIPKQFL QKVTRSGFGR HLFHDWRFLD EAGERPNPAF
     VLNQPPFQQG SILLARENFG CGSSREHAPW ALTDYGFRVV IAPSFADIFY GNAFNSQLLP
     IILDEAQIAA LFTLVSASPG IAFSVDVEQQ TLQAGDTRYT FTLDPFRRHC LIHGLDSIGL
     TLRHASAIDD YEARRPAFLR
//

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