(data stored in ACNUC7421 zone)

SWISSPROT: C6AY95_RHILS

ID   C6AY95_RHILS            Unreviewed;       362 AA.
AC   C6AY95;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 66.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081, ECO:0000256|SAAS:SAAS00703537};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=Rleg_0007 {ECO:0000313|EMBL:ACS54319.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54319.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54319.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54319.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-
CC       dnaK-dnaJ and groELS operons). Prevents heat-shock induction of
CC       these operons. {ECO:0000256|HAMAP-Rule:MF_00081,
CC       ECO:0000256|SAAS:SAAS00703540}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081, ECO:0000256|SAAS:SAAS00703539}.
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DR   EMBL; CP001622; ACS54319.1; -; Genomic_DNA.
DR   RefSeq; WP_012755759.1; NC_012850.1.
DR   ProteinModelPortal; C6AY95; -.
DR   EnsemblBacteria; ACS54319; ACS54319; Rleg_0007.
DR   GeneID; 23434140; -.
DR   KEGG; rlg:Rleg_0007; -.
DR   HOGENOM; HOG000058933; -.
DR   KO; K03705; -.
DR   OMA; GPKRMDY; -.
DR   OrthoDB; POG091H01WV; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF_dom-like.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   PANTHER; PTHR34824:SF2; PTHR34824:SF2; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF55781; SSF55781; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6AY95.
DR   SWISS-2DPAGE; C6AY95.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   Repressor {ECO:0000256|HAMAP-Rule:MF_00081,
KW   ECO:0000256|SAAS:SAAS00703534};
KW   Stress response {ECO:0000256|HAMAP-Rule:MF_00081,
KW   ECO:0000256|SAAS:SAAS00703542};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00081,
KW   ECO:0000256|SAAS:SAAS00703533};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00081,
KW   ECO:0000256|SAAS:SAAS00703547}.
FT   DOMAIN      119    344       HrcA. {ECO:0000259|Pfam:PF01628}.
SQ   SEQUENCE   362 AA;  39552 MW;  35F1567669A80531 CRC64;
     MGIRSTSVSD AVAALDERSR EIFRRIVEGY LESGEPLGSR NLSRILPMSL SPASVRNVMS
     DLEELGLIYS PHVSAGRLPT QIGLRFFVDA FMQVGDLSAE ERASIDRQVR AESGGNPVES
     MMNEASRMLS GISRGAGLVI TSKSDPVLKH VEFIRLEPTK ALAVLVGDHD QVENRIIELP
     AGVTSSQLTE AANFLNAHMS GQTLPELRKQ LSRLKDDVRH ELDALSRDLV ERGIAVWAGS
     PDEGKPTQLI IRGRANLLEG LAGAEDLDRL RLLFDDLEKK DSLIEILNLA ESGSGVRIFI
     GSENKLFSLS GSSLIVAPYR DDDDRIVGAV GVIGPTRLNY SRIVPMVDYT AQLVSRLSRN
     QL
//

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