(data stored in ACNUC7421 zone)

SWISSPROT: C6AYD4_RHILS

ID   C6AYD4_RHILS            Unreviewed;       908 AA.
AC   C6AYD4;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   08-MAY-2019, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096, ECO:0000256|SAAS:SAAS00039014};
GN   Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Rleg_0047 {ECO:0000313|EMBL:ACS54358.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54358.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54358.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54358.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in
CC       DNA. It is possible that it carries out the mismatch recognition
CC       step. This protein has a weak ATPase activity. {ECO:0000256|HAMAP-
CC       Rule:MF_00096, ECO:0000256|SAAS:SAAS00039026}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000256|HAMAP-Rule:MF_00096, ECO:0000256|RuleBase:RU003756,
CC       ECO:0000256|SAAS:SAAS01078076}.
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DR   EMBL; CP001622; ACS54358.1; -; Genomic_DNA.
DR   RefSeq; WP_012755790.1; NC_012850.1.
DR   EnsemblBacteria; ACS54358; ACS54358; Rleg_0047.
DR   KEGG; rlg:Rleg_0047; -.
DR   HOGENOM; HOG000221407; -.
DR   KO; K03555; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6AYD4.
DR   SWISS-2DPAGE; C6AYD4.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00096,
KW   ECO:0000256|SAAS:SAAS01078081}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00096,
KW   ECO:0000256|RuleBase:RU003756, ECO:0000256|SAAS:SAAS01084643};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00096,
KW   ECO:0000256|RuleBase:RU003756, ECO:0000256|SAAS:SAAS00459082};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00096,
KW   ECO:0000256|RuleBase:RU003756, ECO:0000256|SAAS:SAAS01078087};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00096,
KW   ECO:0000256|RuleBase:RU003756, ECO:0000256|SAAS:SAAS01078084}.
FT   DOMAIN      736    752       DNA_MISMATCH_REPAIR_2.
FT                                {ECO:0000259|PROSITE:PS00486}.
FT   NP_BIND     662    669       ATP. {ECO:0000256|HAMAP-Rule:MF_00096}.
FT   COILED      538    565       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   908 AA;  98251 MW;  4DD4ADBD0BED75ED CRC64;
     MNARIDTGNE AFSAAELATA ESRASATPMM EQFIEIKANN PGSLLFYRMG DFYELFFEDA
     LEASRALGIT LTKRGQHMGQ DIPMCGVPVH AADDYLQKLI SLGFRVAVCE QIEDPAEAKK
     RGAKSVVKRD VVRLVTPGTI TEEKLLSPSE SNYLMALTRI RASGEALLAL AWIDISTGVF
     RLAETEASRL LADILRIDPR ELILPDTIFH DPELKPVFDV LGRTAVPQPS VLFDSASAEG
     RIARYFGVAT LDGFGTFSRA ELAAAAAAVA YVEKTQIAER PPLGKPERES AASTLFIDPA
     TRANLELART LSGDRNGSLL KAIDRTVTGG GARLLAERLM SPLTDPARIN ARLDSIGFLI
     DEPLLCGNLR DTLKHVPDMP RALSRLALDR GGPRDLWAIR QGLEAAGGIA AMLGKAMLPE
     ELGQALSGLQ ALPAAVEKLL AETLADELPL LKRDGGFLRD GASAELDEVR ALRDQSRRVI
     AGLQLQYAEE TGIRSLKIKH NNVLGYFIEV TAGNASPMTE TAEAKARFIH RQTMANAMRF
     TTTELADLES RIANAADQAL TIELEAFDRM TAAVVAEAEA IKSGARALAV IDVAAGLALL
     AEEQAYCRPQ VDGSKMFAIE GGRHPVVEQA LRRQAGGPFV ANHCDLSPRT GDRDGAIWLL
     TGPNMGGKST FLRQNALISI LAQMGSFVPA TSAHIGIVDR LFSRVGASDD LARGRSTFMV
     EMVETAAILN QASDRSLVIL DEIGRGTATF DGLSIAWAAV EHLHEANRCR GLFATHFHEL
     TVLSEKLGRL SNATMRVKEW DGDVIFLHEV GPGAADRSYG IQVARLAGLP ASVVARARDV
     LTRLEDADRK NPASQLIDDL PLFQVAVRRE ETARGTSKVE EALKAMSLDD MTPREAMDAL
     YDLKKKLK
//

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