(data stored in ACNUC7421 zone)

SWISSPROT: C6AZ68_RHILS

ID   C6AZ68_RHILS            Unreviewed;       358 AA.
AC   C6AZ68;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   30-AUG-2017, entry version 66.
DE   SubName: Full=Methylated-DNA/protein-cysteine methyltransferase {ECO:0000313|EMBL:ACS54394.1};
GN   OrderedLocusNames=Rleg_0083 {ECO:0000313|EMBL:ACS54394.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54394.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54394.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54394.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000409-3};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR000409-
CC       3};
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00593}.
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DR   EMBL; CP001622; ACS54394.1; -; Genomic_DNA.
DR   RefSeq; WP_012755824.1; NC_012850.1.
DR   ProteinModelPortal; C6AZ68; -.
DR   EnsemblBacteria; ACS54394; ACS54394; Rleg_0083.
DR   KEGG; rlg:Rleg_0083; -.
DR   HOGENOM; HOG000244139; -.
DR   KO; K10778; -.
DR   OMA; GVFCRLT; -.
DR   OrthoDB; POG091H02CY; -.
DR   BioCyc; RLEG395491:GHX2-83-MONOMER; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0003908; F:methylated-DNA-[protein]-cysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd06445; ATase; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.10.10; -; 1.
DR   InterPro; IPR035451; Ada-like_domain.
DR   InterPro; IPR004026; Ada_DNA_repair_Zn-bd.
DR   InterPro; IPR016221; Bifunct_regulatory_prot_Ada.
DR   InterPro; IPR009057; Homeobox-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR001497; MethylDNA_cys_MeTrfase_AS.
DR   InterPro; IPR014048; MethylDNA_cys_MeTrfase_DNA-bd.
DR   InterPro; IPR008332; MethylG_MeTrfase_N.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF02805; Ada_Zn_binding; 1.
DR   Pfam; PF01035; DNA_binding_1; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PIRSF; PIRSF000409; Ada; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF46767; SSF46767; 1.
DR   SUPFAM; SSF53155; SSF53155; 1.
DR   SUPFAM; SSF57884; SSF57884; 1.
DR   TIGRFAMs; TIGR00589; ogt; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
DR   PROSITE; PS00374; MGMT; 1.
PE   4: Predicted;
DR   PRODOM; C6AZ68.
DR   SWISS-2DPAGE; C6AZ68.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00593,
KW   ECO:0000256|SAAS:SAAS00048696};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000409-3};
KW   Methyltransferase {ECO:0000313|EMBL:ACS54394.1};
KW   Transcription {ECO:0000256|PROSITE-ProRule:PRU00593};
KW   Transcription regulation {ECO:0000256|PROSITE-ProRule:PRU00593};
KW   Transferase {ECO:0000313|EMBL:ACS54394.1};
KW   Zinc {ECO:0000256|PIRSR:PIRSR000409-3}.
FT   DOMAIN      110    180       HTH araC/xylS-type DNA-binding.
FT                                {ECO:0000259|PROSITE:PS01124}.
FT   DNA_BIND    147    170       H-T-H motif. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00593}.
FT   ACT_SITE     37     37       Nucleophile; methyl group acceptor from
FT                                phosphotriester. {ECO:0000256|PIRSR:
FT                                PIRSR000409-1}.
FT   ACT_SITE    317    317       Nucleophile; methyl group acceptor from
FT                                either O6-methylguanine or O4-
FT                                methylthymine. {ECO:0000256|PIRSR:
FT                                PIRSR000409-1}.
FT   METAL        37     37       Zinc. {ECO:0000256|PIRSR:PIRSR000409-3}.
FT   METAL        41     41       Zinc. {ECO:0000256|PIRSR:PIRSR000409-3}.
FT   METAL        68     68       Zinc. {ECO:0000256|PIRSR:PIRSR000409-3}.
FT   METAL        71     71       Zinc. {ECO:0000256|PIRSR:PIRSR000409-3}.
SQ   SEQUENCE   358 AA;  40359 MW;  1054DD840E8EF5EA CRC64;
     MLFERPNDDT LYDALIARSA DYEGQAYVCV KTTGIFCRLT CPARKPKREN TLFFDTIAAC
     MHSGFRPCQR CRPLEQPGRE PIVDELLAAL DREPQLRWSE DELVRRGHDP STVRRAFKRG
     LGMTFHDIVR YRRLGEAARQ LADGARVIDA QLEAGYDSPS GFRTAFQRLV GKAPALSQNR
     ELLFADWFET PLGPMVAVAD RTHLHLLEFH DRKALPTELE ALQKRVRSSV AIGRTPAIDQ
     IEAEIRDYFE GRLTVFKTPL ALGGTPFEKH VWAKLMDITA GQTRAYGDLA REMERPEVVR
     AVGRANGANQ LAIIVPCHRI LGADGSLTGY GGGLWRKQWL LRHEEKIRAQ APNVEETA
//

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