(data stored in ACNUC7421 zone)

SWISSPROT: C6AZ70_RHILS

ID   C6AZ70_RHILS            Unreviewed;       382 AA.
AC   C6AZ70;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   30-AUG-2017, entry version 51.
DE   SubName: Full=FMN-dependent alpha-hydroxy acid dehydrogenase {ECO:0000313|EMBL:ACS54396.1};
GN   OrderedLocusNames=Rleg_0085 {ECO:0000313|EMBL:ACS54396.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54396.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54396.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54396.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000256|PROSITE-
CC         ProRule:PRU00683};
CC   -!- SIMILARITY: Belongs to the FMN-dependent alpha-hydroxy acid
CC       dehydrogenase family. {ECO:0000256|PROSITE-ProRule:PRU00683}.
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DR   EMBL; CP001622; ACS54396.1; -; Genomic_DNA.
DR   RefSeq; WP_012755826.1; NC_012850.1.
DR   ProteinModelPortal; C6AZ70; -.
DR   EnsemblBacteria; ACS54396; ACS54396; Rleg_0085.
DR   KEGG; rlg:Rleg_0085; -.
DR   HOGENOM; HOG000217464; -.
DR   KO; K00101; -.
DR   OMA; SCWVILY; -.
DR   OrthoDB; POG091H00L7; -.
DR   BioCyc; RLEG395491:GHX2-85-MONOMER; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd02809; alpha_hydroxyacid_oxid_FMN; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012133; Alpha-hydoxy_acid_DH_FMN.
DR   InterPro; IPR000262; FMN-dep_DH.
DR   InterPro; IPR008259; FMN_hydac_DH_AS.
DR   Pfam; PF01070; FMN_dh; 1.
DR   PIRSF; PIRSF000138; Al-hdrx_acd_dh; 1.
DR   PROSITE; PS00557; FMN_HYDROXY_ACID_DH_1; 1.
DR   PROSITE; PS51349; FMN_HYDROXY_ACID_DH_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6AZ70.
DR   SWISS-2DPAGE; C6AZ70.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   Flavoprotein {ECO:0000256|PROSITE-ProRule:PRU00683};
KW   FMN {ECO:0000256|PROSITE-ProRule:PRU00683}.
FT   DOMAIN       16    378       FMN_dh. {ECO:0000259|Pfam:PF01070}.
FT   NP_BIND     309    333       FMN. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00683}.
FT   ACT_SITE    278    278       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000138-1, ECO:0000256|PROSITE-
FT                                ProRule:PRU00683}.
FT   BINDING      27     27       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00683}.
FT   BINDING     109    109       FMN. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00683}.
FT   BINDING     130    130       FMN. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00683}.
FT   BINDING     132    132       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00683}.
FT   BINDING     158    158       FMN. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00683}.
FT   BINDING     167    167       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00683}.
FT   BINDING     254    254       FMN. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00683}.
FT   BINDING     281    281       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00683}.
SQ   SEQUENCE   382 AA;  42303 MW;  5C8A1F65C6E284AD CRC64;
     MRLTDCYNFH DFRRMAKRRL PGPIFDYIDG GADDEVTYRR NTAAFEACDL VPDVLRGVAD
     VDMSVTVMGQ KLAMPVYCSP TALQRLFHHQ GERAVAAAAA KHGTMFGVSS LGTISLEEAR
     QISNGPQVYQ FYFHKDRGLN REMMARAKNA GVQAMMLTVD SITGGNRERD KRTGFAIPFK
     LNLAGMTQFA IKPSWAIDWL THERFRLPQL ENHVKMDGGA LSISRYFTEM LDPSMSWDDV
     AEMVREWGGP FCLKGIMSVE DAKRAAEIGC SGIVLSNHGG RQLDGSRSAF DQLAEIVDAV
     GDRVDVMMDG GVQRGTHVLK ALSLGAKAVG LGRYYLFPLA AAGQPGVERA LETMRTEIER
     GMKLMGCTSV SQLSRRNLRF RS
//

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