(data stored in ACNUC7421 zone)

SWISSPROT: C6AZ80_RHILS

ID   C6AZ80_RHILS            Unreviewed;       597 AA.
AC   C6AZ80;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 62.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000256|HAMAP-Rule:MF_01810, ECO:0000256|SAAS:SAAS00003942};
DE   AltName: Full=Foldase YidC {ECO:0000256|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000256|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN   OrderedLocusNames=Rleg_0095 {ECO:0000313|EMBL:ACS54406.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54406.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54406.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54406.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as
CC       well as at least some lipoproteins. Aids folding of multispanning
CC       membrane proteins. {ECO:0000256|SAAS:SAAS00721203}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent
CC       integral membrane proteins during membrane integration.
CC       {ECO:0000256|HAMAP-Rule:MF_01810, ECO:0000256|SAAS:SAAS00721205}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1
CC       subfamily. {ECO:0000256|SAAS:SAAS00536017}.
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DR   EMBL; CP001622; ACS54406.1; -; Genomic_DNA.
DR   RefSeq; WP_012755832.1; NC_012850.1.
DR   EnsemblBacteria; ACS54406; ACS54406; Rleg_0095.
DR   KEGG; rlg:Rleg_0095; -.
DR   HOGENOM; HOG000101821; -.
DR   KO; K03217; -.
DR   OMA; INPVAGC; -.
DR   OrthoDB; POG091H00BE; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051205; P:protein insertion into membrane; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; Membrane_insert_OXA1/ALB3/YidC.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6AZ80.
DR   SWISS-2DPAGE; C6AZ80.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01810};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01810,
KW   ECO:0000256|SAAS:SAAS00003987};
KW   Chaperone {ECO:0000256|HAMAP-Rule:MF_01810,
KW   ECO:0000256|SAAS:SAAS00003966};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01810,
KW   ECO:0000256|SAAS:SAAS00115372};
KW   Protein transport {ECO:0000256|HAMAP-Rule:MF_01810,
KW   ECO:0000256|SAAS:SAAS00003970};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01810,
KW   ECO:0000256|SAAS:SAAS00474781};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01810,
KW   ECO:0000256|SAAS:SAAS00115422};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01810,
KW   ECO:0000256|SAAS:SAAS00003955}.
FT   TRANSMEM      6     25       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01810}.
FT   TRANSMEM    372    395       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01810}.
FT   TRANSMEM    501    520       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01810}.
FT   TRANSMEM    532    559       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01810}.
FT   DOMAIN       86    365       YidC_periplas. {ECO:0000259|Pfam:
FT                                PF14849}.
SQ   SEQUENCE   597 AA;  66401 MW;  F9206C1F6CE61B71 CRC64;
     MENNRNYFIA IALSVLIVLG WQFLYMNPRI EAQRKVQEAQ KAQQQTEQVQ QPAAGGQTPA
     QPSGAAPTSQ AAATATLEQA LAKSPRVVID TAALSGSINL AGARLDDLKL KGYHETVDDS
     SPIITLFSPA ETKDGYFTEL GYIGSDATGS VPGPSTLWTA PEGAKLTEKT PVTLSYTNDK
     GLTFTRTISV DERYMFTVAD KIENAGQAPA SLNSYGRVTR YNKPTTPSVY VLHEGFIGVI
     GDDGLVETKY TAAEKEAVKP AKSTGGWLGI TDKYWAATIV PPQSAPYEAS FSHFADGQPR
     YQADYKEDAF TVAPGQSIEL KNLVFAGAKE VPVIDGYEAS YSIPKFDRLI DWGWFYFITK
     PMFKLMDFFF RYFGNFGVAI LCTTIVVKLL FFPLASKQYA SMANMKRMQP KMEELKAKFA
     DDRMGLQQAT MQLYKEEKIN PIAGCWPVAL QIPIFFSLYK VIYITIEMRH APFFGWIKDL
     SAPDPTTIVN LFGLLPFEAP TILHLGVWPL IMGVTMFLQM RMNPTPPDPT QAMIFTWMPL
     VFMFMLASFP AGLVIYWAWN NTLSVAQQSV IMKRHGVKVE LFDNLKGLFR RKTAPSK
//

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