(data stored in ACNUC7421 zone)

SWISSPROT: C6AZC7_RHILS

ID   C6AZC7_RHILS            Unreviewed;       471 AA.
AC   C6AZC7;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 46.
DE   RecName: Full=Trehalose-6-phosphate synthase {ECO:0000256|RuleBase:RU362045};
DE            EC=2.4.1.15 {ECO:0000256|RuleBase:RU362045};
DE   AltName: Full=Osmoregulatory trehalose synthesis protein A {ECO:0000256|RuleBase:RU362045};
DE   AltName: Full=UDP-glucose-glucosephosphate glucosyltransferase {ECO:0000256|RuleBase:RU362045};
GN   OrderedLocusNames=Rleg_0142 {ECO:0000313|EMBL:ACS54453.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54453.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54453.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54453.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: Probably involved in the osmoprotection via the
CC       biosynthesis of trehalose. Catalyzes the transfer of glucose from
CC       UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form
CC       trehalose-6-phosphate. Acts with retention of the anomeric
CC       configuration of the UDP-sugar donor.
CC       {ECO:0000256|RuleBase:RU362045}.
CC   -!- CATALYTIC ACTIVITY: UDP-glucose + D-glucose 6-phosphate = UDP +
CC       alpha,alpha-trehalose 6-phosphate.
CC       {ECO:0000256|RuleBase:RU362045}.
CC   -!- PATHWAY: Glycan biosynthesis; trehalose biosynthesis.
CC       {ECO:0000256|RuleBase:RU362045}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU362045}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 20 family.
CC       {ECO:0000256|RuleBase:RU362045}.
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DR   EMBL; CP001622; ACS54453.1; -; Genomic_DNA.
DR   RefSeq; WP_012755875.1; NC_012850.1.
DR   ProteinModelPortal; C6AZC7; -.
DR   CAZy; GT20; Glycosyltransferase Family 20.
DR   EnsemblBacteria; ACS54453; ACS54453; Rleg_0142.
DR   KEGG; rlg:Rleg_0142; -.
DR   HOGENOM; HOG000191478; -.
DR   KO; K00697; -.
DR   OMA; IEFMPIH; -.
DR   OrthoDB; POG091H0ASR; -.
DR   BioCyc; RLEG395491:GHX2-143-MONOMER; -.
DR   UniPathway; UPA00299; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0003825; F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity; IEA:UniProtKB-EC.
DR   GO; GO:0005992; P:trehalose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd03788; GT1_TPS; 1.
DR   InterPro; IPR001830; Glyco_trans_20.
DR   InterPro; IPR012766; Trehalose_OtsA.
DR   Pfam; PF00982; Glyco_transf_20; 1.
DR   TIGRFAMs; TIGR02400; trehalose_OtsA; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6AZC7.
DR   SWISS-2DPAGE; C6AZC7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU362045,
KW   ECO:0000313|EMBL:ACS54453.1};
KW   Transferase {ECO:0000256|RuleBase:RU362045,
KW   ECO:0000313|EMBL:ACS54453.1}.
FT   DOMAIN        4    455       Glyco_transf_20. {ECO:0000259|Pfam:
FT                                PF00982}.
SQ   SEQUENCE   471 AA;  52718 MW;  6B59A944DFDDA6DA CRC64;
     MSRLVVVSNR VPMPAKDGSA AAGGLAVALQ AALQERGGIW MGWSGESSGD REPGPLSQLQ
     KGNITYALTD LTDTDVEEYY RGFANRVLWP ICHYRLDLAE YGRKEMAGYF RVNRFFAHRL
     APMIEPDDII WVHDYHLIPL AAELRQMGLK NRIGFFLHIP WPPADILVTM PVHEEIMRGL
     SHYDLVGFQT DYDLQNFAGY LRREGIGDDL GNGLFDSHGR IFKAGAYPIG IETAAFAEFA
     ERAANNIMVQ KTRRSVEGRD MIIGVDRLDY SKGIIQRLEA FETFLTSNPA YQNKVTYLQV
     TPKSRSEVPE YEHMQGMVAE QAGRVNGAIG TVDWVPIRYV NRSISRNVLA GLYRLATIGL
     VTPLRDGMNL VAKEYVAAQD PDRPGVLVLS RFAGAARELK GALLVNPYDV EGTANAIAKG
     LAMSLEERRD RWSMMMEHLL THDVSLWCEN FLGDLVLAPE LRPERDSRIG S
//

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