(data stored in ACNUC7421 zone)

SWISSPROT: C6B0D6_RHILS

ID   C6B0D6_RHILS            Unreviewed;       737 AA.
AC   C6B0D6;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 54.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase NAD-binding {ECO:0000313|EMBL:ACS54555.1};
GN   OrderedLocusNames=Rleg_0244 {ECO:0000313|EMBL:ACS54555.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54555.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54555.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54555.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- CATALYTIC ACTIVITY: (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA
CC       + NADH. {ECO:0000256|SAAS:SAAS00379695}.
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00649747}.
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DR   EMBL; CP001622; ACS54555.1; -; Genomic_DNA.
DR   RefSeq; WP_012755969.1; NC_012850.1.
DR   ProteinModelPortal; C6B0D6; -.
DR   EnsemblBacteria; ACS54555; ACS54555; Rleg_0244.
DR   KEGG; rlg:Rleg_0244; -.
DR   HOGENOM; HOG000261345; -.
DR   KO; K01782; -.
DR   OMA; PFRYMDT; -.
DR   OrthoDB; POG091H0NDD; -.
DR   BioCyc; RLEG395491:GHX2-247-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR013328; 6PGD_dom_2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom.
DR   InterPro; IPR001753; Crotonase_core_superfam.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
DR   PRODOM; C6B0D6.
DR   SWISS-2DPAGE; C6B0D6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00456821};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00456809};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00656508}.
FT   DOMAIN      328    507       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      509    606       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   737 AA;  78880 MW;  11FAE058E701D1C4 CRC64;
     MTYTNFTLET DADGIALVTW DMPGKSMNVF TAEVMAELDA IIDATTADAA VKGVVFTSGK
     SSFSGGADLS MIKSMFSSYQ EEKAKSPETA VQNLFGLVGR MSGLFRKLEI SGKPWVSAIN
     GTCMGGAFEL SLACHGRVAS NAKSVKIALP EVKVGIFPGA GGTQRVPRLA NAQDALQMMT
     TGQSLTGSRA KAMNLVHQVV EPDQLIPAAK QMIKDGLKPV APWDEKGFKA PGGGIWTPAS
     AQLWPAAPAI LRRETSGNYP AALAILKCVY EGLQVPFDTG LKIEQRYFTE VLQTREAFSM
     IRSLFISMQE LGKGARRPAG HAKTELKHVG VVGAGFMGAS IAYVTAAAGI PVTLIDRDIE
     AATKGKTVSE GLVKDSIGKG RLTQDEAAAL LSRITPSADY ADLANADLVI EAVFEDREVK
     KAVIEAVEAV LPEGAIFASN TSTLPISGLA KNSKRPADFI GIHFFSPVEK MMLTEVILGS
     DTGDKALAVA LDYVAAIRKT PIVVNDTRGF FVNRCVLRYM SESYDMLIEG VPPVMIENAA
     KMAGMPVGPL ALNDEVAIDL SLKILKATVA DLGEKAIDPR HMDLISSMVE KEGRFGRKNS
     KGFYDYPPKP AKKSLWPDLK SFYPQKQADE VDVNVLKQRF LVTIALEAAR TVEEGIVTDP
     READVGSILG FGFAPYTGGA LSYIDGMGAK AFVELAEKLA GTYGKHFKPT PLLKDMAAKG
     ETFYGRFDPY AKVGKAA
//

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