(data stored in ACNUC7421 zone)

SWISSPROT: C6B0J9_RHILS

ID   C6B0J9_RHILS            Unreviewed;       284 AA.
AC   C6B0J9;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 53.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   OrderedLocusNames=Rleg_0307 {ECO:0000313|EMBL:ACS54618.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54618.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54618.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54618.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity.
CC       Binds linear dsDNA with 5'- and 3'- overhangs but not closed
CC       circular dsDNA nor ssDNA. Recruits and stimulates the ligase
CC       activity of LigD. {ECO:0000256|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family.
CC       {ECO:0000256|HAMAP-Rule:MF_01875}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001622; ACS54618.1; -; Genomic_DNA.
DR   RefSeq; WP_012756026.1; NC_012850.1.
DR   ProteinModelPortal; C6B0J9; -.
DR   EnsemblBacteria; ACS54618; ACS54618; Rleg_0307.
DR   KEGG; rlg:Rleg_0307; -.
DR   HOGENOM; HOG000237249; -.
DR   KO; K10979; -.
DR   OMA; IWKGAVS; -.
DR   OrthoDB; POG091H08YK; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-HAMAP.
DR   CDD; cd00789; KU_like; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom.
DR   PANTHER; PTHR41251; PTHR41251; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SSF100939; 1.
DR   TIGRFAMs; TIGR02772; Ku_bact; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6B0J9.
DR   SWISS-2DPAGE; C6B0J9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01875}.
FT   DOMAIN       55    183       Ku. {ECO:0000259|SMART:SM00559}.
SQ   SEQUENCE   284 AA;  31753 MW;  F358EC4F84AA6CD4 CRC64;
     MAARASWKGH LKVGDLACAV GLYTAVSSSD RVSFNIINRR TGHRVERQFV DSETGKPVER
     GDQVKGYQME NGDYIVIEGD EIAEIMPESD KVLNIKAFIA YDDIDKLYFD RPYYLAPVDE
     HDEEALSLIA RGMRDGKVAA LAEAVLFRRN RTLLIRPHDD YIVATMLNFD YEVRSAETVF
     EDIPDIKFDK EMIALAGHII GTKQGSFEPS TYEDRYEAAL VELVKAKIEG RAPPKKKPAP
     ERKVVDLMEA LRQSAKMSGN APAKKALAKK KAPARSDSRS KKAS
//

If you have problems or comments...

PBIL Back to PBIL home page