(data stored in ACNUC7421 zone)

SWISSPROT: C6B1M5_RHILS

ID   C6B1M5_RHILS            Unreviewed;       287 AA.
AC   C6B1M5;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 56.
DE   RecName: Full=Glucose-1-phosphate thymidylyltransferase {ECO:0000256|RuleBase:RU003706};
DE            EC=2.7.7.24 {ECO:0000256|RuleBase:RU003706};
GN   OrderedLocusNames=Rleg_0434 {ECO:0000313|EMBL:ACS54744.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54744.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54744.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54744.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: Catalyzes the formation of dTDP-glucose, from dTTP and
CC       glucose 1-phosphate, as well as its pyrophosphorolysis.
CC       {ECO:0000256|RuleBase:RU003706}.
CC   -!- CATALYTIC ACTIVITY: dTTP + alpha-D-glucose 1-phosphate =
CC       diphosphate + dTDP-alpha-D-glucose.
CC       {ECO:0000256|RuleBase:RU003706}.
CC   -!- SIMILARITY: Belongs to the glucose-1-phosphate
CC       thymidylyltransferase family. {ECO:0000256|RuleBase:RU003706}.
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DR   EMBL; CP001622; ACS54744.1; -; Genomic_DNA.
DR   RefSeq; WP_012756132.1; NC_012850.1.
DR   ProteinModelPortal; C6B1M5; -.
DR   EnsemblBacteria; ACS54744; ACS54744; Rleg_0434.
DR   KEGG; rlg:Rleg_0434; -.
DR   HOGENOM; HOG000283473; -.
DR   KO; K00973; -.
DR   OMA; YFYPAGV; -.
DR   OrthoDB; POG091H050O; -.
DR   BioCyc; RLEG395491:GHX2-439-MONOMER; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0008879; F:glucose-1-phosphate thymidylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR   CDD; cd02538; G1P_TT_short; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005907; G1P_thy_trans_s.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43532; PTHR43532; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01207; rmlA; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6B1M5.
DR   SWISS-2DPAGE; C6B1M5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   Magnesium {ECO:0000256|RuleBase:RU003706};
KW   Metal-binding {ECO:0000256|RuleBase:RU003706};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU003706};
KW   Transferase {ECO:0000256|RuleBase:RU003706,
KW   ECO:0000313|EMBL:ACS54744.1}.
FT   DOMAIN        2    235       NTP_transferase. {ECO:0000259|Pfam:
FT                                PF00483}.
SQ   SEQUENCE   287 AA;  31240 MW;  65B4EABD10CF6F29 CRC64;
     MKGIVLAGGS GSRLHPMTHA VSKQLLPIYD KPMIYYPLTT LMLAGIREVL IISTPHDMPL
     FQRLLGDGSE WGMSLSYAVQ PSPDGLAQAY IIGADFVAGG PSCLILGDNI YFGHGLPELL
     EEGVSKGDGA TIFAYHVHDP ERYGVVEFGS DMTAISIEEK PAKPKSHWAV TGLYFYDADV
     VDIAANLKPS ARGEYEITDV NKTYLERGKL RVSMMGRGYA WLDTGTPESL LEAGGFVRTL
     EKRQGFKIAC PEEIALAKGF ITKERFAQIA AQAGKGDYGQ YLRGLVD
//

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