(data stored in ACNUC7421 zone)

SWISSPROT: C6B1M6_RHILS

ID   C6B1M6_RHILS            Unreviewed;       297 AA.
AC   C6B1M6;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   30-AUG-2017, entry version 48.
DE   RecName: Full=dTDP-4-dehydrorhamnose reductase {ECO:0000256|RuleBase:RU364082};
DE            EC=1.1.1.133 {ECO:0000256|RuleBase:RU364082};
GN   OrderedLocusNames=Rleg_0435 {ECO:0000313|EMBL:ACS54745.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54745.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54745.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54745.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-
CC       hexulose to yield dTDP-L-rhamnose.
CC       {ECO:0000256|RuleBase:RU364082}.
CC   -!- CATALYTIC ACTIVITY: dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-
CC       dehydro-beta-L-rhamnose + NADPH. {ECO:0000256|RuleBase:RU364082}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU364082};
CC       Note=Binds 1 Mg(2+) ion per monomer.
CC       {ECO:0000256|RuleBase:RU364082};
CC   -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.
CC       {ECO:0000256|RuleBase:RU364082}.
CC   -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose reductase
CC       family. {ECO:0000256|RuleBase:RU364082}.
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DR   EMBL; CP001622; ACS54745.1; -; Genomic_DNA.
DR   RefSeq; WP_012756133.1; NC_012850.1.
DR   ProteinModelPortal; C6B1M6; -.
DR   EnsemblBacteria; ACS54745; ACS54745; Rleg_0435.
DR   KEGG; rlg:Rleg_0435; -.
DR   HOGENOM; HOG000227712; -.
DR   KO; K00067; -.
DR   OMA; AYRINAI; -.
DR   OrthoDB; POG091H07IL; -.
DR   BioCyc; RLEG395491:GHX2-440-MONOMER; -.
DR   UniPathway; UPA00124; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0008831; F:dTDP-4-dehydrorhamnose reductase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR005913; dTDP_dehydrorham_reduct.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR029903; RmlD-like-bd.
DR   PANTHER; PTHR10491; PTHR10491; 1.
DR   Pfam; PF04321; RmlD_sub_bind; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01214; rmlD; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6B1M6.
DR   SWISS-2DPAGE; C6B1M6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   NADP {ECO:0000256|RuleBase:RU364082};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU364082,
KW   ECO:0000313|EMBL:ACS54745.1}.
FT   DOMAIN        1    289       RmlD_sub_bind. {ECO:0000259|Pfam:
FT                                PF04321}.
SQ   SEQUENCE   297 AA;  31594 MW;  EAB33C121C71FBA8 CRC64;
     MRIAVTGKSG QVTSALQALN VPGIEIIAIG RPELDLLEPS MVSEIIAKIK PDVVVSSAAY
     TAVDKAESDE AAAFAINRDG AKAIAAATAE LSLPVIHLST DYVFDGDKPE CYVESDPVGP
     VSVYGRSKLE GEYAVAAANE NHVILRTAWV YSTFGHNFVI TMLRLAETRE ELSVVSDQLG
     CPTSAGDIAG AIVKIAGRLS NDSTPDLRGV CHLAGSGETS CAGFARYILS IHEEKTGRRV
     TVKDIATADY PTAAKRPANS RLCCDKLKSL YSVSMPEWRI SARAAVTKLL EEPKEAV
//

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