(data stored in ACNUC7421 zone)

SWISSPROT: C6B1M9_RHILS

ID   C6B1M9_RHILS            Unreviewed;       360 AA.
AC   C6B1M9;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 56.
DE   RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|HAMAP-Rule:MF_00955};
DE            EC=4.2.1.47 {ECO:0000256|HAMAP-Rule:MF_00955};
DE   AltName: Full=GDP-D-mannose dehydratase {ECO:0000256|HAMAP-Rule:MF_00955};
GN   Name=gmd {ECO:0000256|HAMAP-Rule:MF_00955};
GN   OrderedLocusNames=Rleg_0439 {ECO:0000313|EMBL:ACS54748.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54748.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54748.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54748.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-
CC       dehydro-6-deoxy-D-mannose. {ECO:0000256|HAMAP-Rule:MF_00955}.
CC   -!- CATALYTIC ACTIVITY: GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-
CC       rhamnose + H(2)O. {ECO:0000256|HAMAP-Rule:MF_00955}.
CC   -!- COFACTOR:
CC       Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00955};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. GDP-mannose 4,6-dehydratase subfamily. {ECO:0000256|HAMAP-
CC       Rule:MF_00955}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00955}.
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DR   EMBL; CP001622; ACS54748.1; -; Genomic_DNA.
DR   RefSeq; WP_012756136.1; NC_012850.1.
DR   ProteinModelPortal; C6B1M9; -.
DR   EnsemblBacteria; ACS54748; ACS54748; Rleg_0439.
DR   KEGG; rlg:Rleg_0439; -.
DR   HOGENOM; HOG000168003; -.
DR   KO; K01711; -.
DR   OMA; TDCLYLG; -.
DR   OrthoDB; POG091H0MRZ; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0070401; F:NADP+ binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR   HAMAP; MF_00955; GDP_Man_dehydratase; 1.
DR   InterPro; IPR006368; GDP_Man_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01472; gmd; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6B1M9.
DR   SWISS-2DPAGE; C6B1M9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00955};
KW   NADP {ECO:0000256|HAMAP-Rule:MF_00955}.
FT   DOMAIN        5    334       NAD(P)-bd_dom. {ECO:0000259|Pfam:
FT                                PF16363}.
SQ   SEQUENCE   360 AA;  41348 MW;  DA1381E759B5D015 CRC64;
     MKRALITGIT GQDGSYLAEL LIEKGYEVHG IKRRTSLFNT DRIDHLYQDP HDTNRRLVLH
     YGDMTDSSSL VRIVQQVQPD EIYNLAAQSH VAVSFEEPEY TANSDALGAL RILEAIRILG
     LEKKTRFYQA STSELYGLVQ EIPQRETTPF YPRSPYAVAK LYAYWITVNY REAYGIYACN
     GILFNHESPV RGETFVTRKI TRALARIKLG LQDCLYLGNL DAKRDWGHAK DYVEMQWLML
     QQDEPEDFVI ATGVQYSVRE FVDAAAHEIG LPISWKGSGA EEKGYDENGR CIVAVDPRYF
     RPTEVETLLG DPSKAKEKLG WEPRITFKQL VEEMMREDLK SAERDELVKR HGFSAYDYHE
//

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