(data stored in ACNUC7421 zone)

SWISSPROT: C6B2J5_RHILS

ID   C6B2J5_RHILS            Unreviewed;       373 AA.
AC   C6B2J5;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 65.
DE   RecName: Full=ATP phosphoribosyltransferase regulatory subunit {ECO:0000256|HAMAP-Rule:MF_00125, ECO:0000256|SAAS:SAAS00831814};
GN   Name=hisZ {ECO:0000256|HAMAP-Rule:MF_00125};
GN   OrderedLocusNames=Rleg_0510 {ECO:0000313|EMBL:ACS54815.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54815.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54815.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54815.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: Required for the first step of histidine biosynthesis.
CC       May allow the feedback regulation of ATP phosphoribosyltransferase
CC       activity by histidine. {ECO:0000256|HAMAP-Rule:MF_00125,
CC       ECO:0000256|SAAS:SAAS00831812}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
CC       {ECO:0000256|HAMAP-Rule:MF_00125, ECO:0000256|SAAS:SAAS00831811}.
CC   -!- SUBUNIT: Heteromultimer composed of HisG and HisZ subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00125}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00125,
CC       ECO:0000256|SAAS:SAAS00831808}.
CC   -!- MISCELLANEOUS: This function is generally fulfilled by the C-
CC       terminal part of HisG, which is missing in some bacteria such as
CC       this one. {ECO:0000256|HAMAP-Rule:MF_00125}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family. HisZ subfamily. {ECO:0000256|HAMAP-Rule:MF_00125,
CC       ECO:0000256|SAAS:SAAS00831816}.
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DR   EMBL; CP001622; ACS54815.1; -; Genomic_DNA.
DR   RefSeq; WP_012756201.1; NC_012850.1.
DR   ProteinModelPortal; C6B2J5; -.
DR   EnsemblBacteria; ACS54815; ACS54815; Rleg_0510.
DR   KEGG; rlg:Rleg_0510; -.
DR   HOGENOM; HOG000141880; -.
DR   KO; K02502; -.
DR   OMA; YYTGFEF; -.
DR   OrthoDB; POG091H0GG3; -.
DR   UniPathway; UPA00031; UER00006.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004812; F:aminoacyl-tRNA ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00125; HisZ; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   InterPro; IPR004517; HisZ.
DR   PANTHER; PTHR43707; PTHR43707; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 2.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6B2J5.
DR   SWISS-2DPAGE; C6B2J5.
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00125,
KW   ECO:0000256|SAAS:SAAS00831810};
KW   Aminoacyl-tRNA synthetase {ECO:0000313|EMBL:ACS54815.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00125,
KW   ECO:0000256|SAAS:SAAS00831815};
KW   Histidine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00125,
KW   ECO:0000256|SAAS:SAAS00831813}; Ligase {ECO:0000313|EMBL:ACS54815.1}.
FT   DOMAIN       17    355       AA_TRNA_LIGASE_II. {ECO:0000259|PROSITE:
FT                                PS50862}.
SQ   SEQUENCE   373 AA;  40602 MW;  612F9A155C538B0C CRC64;
     MPLINLPEFA NDLIAEFDAR NAERIDTPVI QPAEPFLDIA GEDLRRRIFM TESETGASLC
     LRPEFTIPVC LRHIETATGT PKRYAYLGEV FRQRRDGANE FYQAGIEDLG DIDLSNADAR
     AIGDATGILA RLLPGRRLAV TLGDQAVFEA VVQALGLPLG WQKRLIHAFG NMTQLEALLA
     SLVSPQFVTG LDDDIARLVA SDDEQALVAY LEREMQKTGY STNAGRSALE IARRLKEKLI
     LSETRLDDAA FRVLEEFLSL DVPLINASAA LSGFADAAGL KLGNALARFN GRVAALSNAG
     VDLSCLDYRA AFGRPLDYYT GLVFEVTVEG STAVLAGGGR FDRLLTFLGA TDRIPAVGFS
     FWLDRIETER AAA
//

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