(data stored in ACNUC7421 zone)

SWISSPROT: C6B2M3_RHILS

ID   C6B2M3_RHILS            Unreviewed;       600 AA.
AC   C6B2M3;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 64.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149, ECO:0000256|SAAS:SAAS00673670};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=Rleg_0539 {ECO:0000313|EMBL:ACS54843.1};
OS   Rhizobium leguminosarum bv. trifolii (strain WSM1325).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS54843.1, ECO:0000313|Proteomes:UP000002256};
RN   [1] {ECO:0000313|EMBL:ACS54843.1, ECO:0000313|Proteomes:UP000002256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM1325 {ECO:0000313|EMBL:ACS54843.1,
RC   ECO:0000313|Proteomes:UP000002256};
RX   PubMed=21304718;
RA   Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K.,
RA   Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M.,
RA   Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N.,
RA   Melino V., Denton M., Yates R., Howieson J.;
RT   "Complete genome sequence of Rhizobium leguminosarum bv. trifolii
RT   strain WSM1325, an effective microsymbiont of annual Mediterranean
RT   clovers.";
RL   Stand. Genomic Sci. 2:347-356(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in
CC       DNA. It is required for dam-dependent methyl-directed DNA mismatch
CC       repair. May act as a "molecular matchmaker", a protein that
CC       promotes the formation of a stable complex between two or more
CC       DNA-binding proteins in an ATP-dependent manner without itself
CC       being part of a final effector complex. {ECO:0000256|HAMAP-
CC       Rule:MF_00149, ECO:0000256|SAAS:SAAS00673673}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00149, ECO:0000256|SAAS:SAAS00642435}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001622; ACS54843.1; -; Genomic_DNA.
DR   RefSeq; WP_012756225.1; NC_012850.1.
DR   ProteinModelPortal; C6B2M3; -.
DR   EnsemblBacteria; ACS54843; ACS54843; Rleg_0539.
DR   KEGG; rlg:Rleg_0539; -.
DR   HOGENOM; HOG000256550; -.
DR   KO; K03572; -.
DR   OMA; QHIAHER; -.
DR   OrthoDB; POG091H015A; -.
DR   Proteomes; UP000002256; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR013507; DNA_mismatch_repair_C.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR002099; DNA_mismatch_repair_fam.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6B2M3.
DR   SWISS-2DPAGE; C6B2M3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002256};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00149,
KW   ECO:0000256|SAAS:SAAS00642434};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00149,
KW   ECO:0000256|SAAS:SAAS00635431}.
FT   DOMAIN      207    325       DNA_mis_repair. {ECO:0000259|SMART:
FT                                SM01340}.
FT   DOMAIN      414    557       MutL_C. {ECO:0000259|SMART:SM00853}.
SQ   SEQUENCE   600 AA;  64564 MW;  DAC89773F457358A CRC64;
     MAIRQLSETL INQIAAGEVI ERPASAAKEL IENALDAGAT RIEIATSGGG KALLRVSDNG
     SGMDAADLEL AVRRHCTSKI SETLEDIRTL GFRGEALPSI GSVARLSIAS RRRDSTGGHE
     IAVAGGKIAH MRPAAANPGT IVEVRDLFFA TPARLKFLKT EKAEAGAITE IVKRMAIAFP
     AVRFVLSGSD RTTLEFPATG DDHLARMAQV LGKEFRDNAI ALDAVREEIA LTGFAGVPTF
     NRGNSAHQYA FVNGRPVQDK LILSAIRGAY AETIPSGRYP VAVLAITLDP ALVDVNVHPA
     KSDVRFRDPS LVRGLIVGAI REALARDGSR AATTGASDML RSFRPGFQPN NQRPQTAWSA
     ETSPSQPYQP ATGFGERPQA SFDGLSMPTA RAEPQFSPQP AVAEPNTRYP LGAARAQIHA
     NYIVAQTEDG LVIVDQHAAH ERLVFEAMRK ALHSKRLASQ VLLIPEIVDI PEEDCDRLMQ
     HAAELSELGL AIERFGPGAI AVRETPAMLG EVDAHGLIRQ LADEIAEWDT ASGLSAKLEY
     VAATMACHGS VRSGRRLRPE EMNALLREME VTPGSGQCNH GRPTYIELKL SDIERLFGRS
//

If you have problems or comments...

PBIL Back to PBIL home page