(data stored in ACNUC7421 zone)

SWISSPROT: C6WF40_ACTMD

ID   C6WF40_ACTMD            Unreviewed;       713 AA.
AC   C6WF40;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   30-AUG-2017, entry version 53.
DE   RecName: Full=DNA polymerase III subunit gamma/tau {ECO:0000256|RuleBase:RU364063};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU364063};
GN   Name=dnaX {ECO:0000256|RuleBase:RU364063};
GN   OrderedLocusNames=Amir_0201 {ECO:0000313|EMBL:ACU34172.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34172.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34172.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria.
CC       This DNA polymerase also exhibits 3' to 5' exonuclease activity.
CC       {ECO:0000256|RuleBase:RU364063}.
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1). {ECO:0000256|RuleBase:RU364063}.
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha,
CC       epsilon and theta chains) that associates with a tau subunit. This
CC       core dimerizes to form the POLIII' complex. PolIII' associates
CC       with the gamma complex (composed of gamma, delta, delta', psi and
CC       chi chains) and with the beta chain to form the complete DNA
CC       polymerase III complex. {ECO:0000256|RuleBase:RU364063}.
CC   -!- SIMILARITY: Belongs to the DnaX/STICHEL family.
CC       {ECO:0000256|RuleBase:RU364063}.
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DR   EMBL; CP001630; ACU34172.1; -; Genomic_DNA.
DR   STRING; 446462.Amir_0201; -.
DR   EnsemblBacteria; ACU34172; ACU34172; Amir_0201.
DR   KEGG; ami:Amir_0201; -.
DR   eggNOG; ENOG4107QMP; Bacteria.
DR   eggNOG; COG2812; LUCA.
DR   HOGENOM; HOG000083933; -.
DR   KO; K02343; -.
DR   OMA; FNATQQR; -.
DR   OrthoDB; POG091H00Y6; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR022754; DNA_pol_III_gamma-3.
DR   InterPro; IPR012763; DNA_pol_III_sug/sutau.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF12169; DNA_pol3_gamma3; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02397; dnaX_nterm; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WF40.
DR   SWISS-2DPAGE; C6WF40.
KW   ATP-binding {ECO:0000256|RuleBase:RU364063};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   DNA replication {ECO:0000256|RuleBase:RU364063};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU364063};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU364063};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU364063,
KW   ECO:0000313|EMBL:ACU34172.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW   Transferase {ECO:0000256|RuleBase:RU364063,
KW   ECO:0000313|EMBL:ACU34172.1}.
FT   DOMAIN       40    184       AAA. {ECO:0000259|SMART:SM00382}.
SQ   SEQUENCE   713 AA;  74819 MW;  716BE0F76A70C7A4 CRC64;
     MVRPVALALY RKYRPATFAE VIGQEHVTDP LRIALGAGRV NHAYLFSGPR GCGKTSSARI
     LARSLNCAKG PTPDPCGECN SCVGLAPNGP GSVDVVELDA ASHGGVDDTR ELREKAFYAP
     AEAKYRVFII DEAHMVTTQG FNALLKIVEE PPEHLIFIFA TTEPDKVLPT IRSRTHHYPF
     RLIPPVSMRA LLERNCAAEG VAVEPSVFPL VIRAGGGSAR DTQSVMDQLL SGAGPEGVRY
     DRAIALLGVT DVALIDDVVE GLAAGDGSAV FGTVDRLVDA GHDPRRFATD LLDRLRDLVL
     LCAVPDAGER GLVSAPEDVL AKMIPQAQNI GPATLTRYAE VLHQGLTDMR GATAPRLLLE
     LLCARMLLPS VSDAESAVLQ RVERLEKHGV AAGGGNGGGG APAVESKFQR PSQRQAEPEP
     APAQAAPQAV APPVAATQIA APPVVAPPAA AQPVAAPAEP TPQPATPQQP AAQARPTAQA
     APQQARFQRP SQSPPQPASA AAEPAAPAAA PASGAVDAVE IRRRWPELLG VVKGASRSTE
     AMLTNATVAE VDGTSVTLTH TSGPLARRLA EQRNAEVIAK AFGQVLGGSW QVRCVQGDAA
     TAQRPQQQSR QARPAPARPS QAESAPAPGH GRQMLEKAMQ AQANRSTGRA GDDIPLPPEP
     DEPDDPLPPE PVDEEEMFAE AARPGEPGEE RLDPEAVVLK LLADELGARP LKS
//

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