(data stored in ACNUC7421 zone)

SWISSPROT: C6WF61_ACTMD

ID   C6WF61_ACTMD            Unreviewed;       484 AA.
AC   C6WF61;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 53.
DE   RecName: Full=Catalase {ECO:0000256|RuleBase:RU000498};
DE            EC=1.11.1.6 {ECO:0000256|RuleBase:RU000498};
GN   OrderedLocusNames=Amir_0222 {ECO:0000313|EMBL:ACU34193.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34193.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34193.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- CATALYTIC ACTIVITY: 2 H(2)O(2) = O(2) + 2 H(2)O.
CC       {ECO:0000256|RuleBase:RU000498}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|PIRSR:PIRSR038928-2};
CC   -!- SIMILARITY: Belongs to the catalase family.
CC       {ECO:0000256|RuleBase:RU000498}.
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DR   EMBL; CP001630; ACU34193.1; -; Genomic_DNA.
DR   RefSeq; WP_012782856.1; NC_013093.1.
DR   STRING; 446462.Amir_0222; -.
DR   EnsemblBacteria; ACU34193; ACU34193; Amir_0222.
DR   KEGG; ami:Amir_0222; -.
DR   eggNOG; ENOG4105CH6; Bacteria.
DR   eggNOG; COG0753; LUCA.
DR   HOGENOM; HOG000087852; -.
DR   KO; K03781; -.
DR   OMA; HADFGRM; -.
DR   OrthoDB; POG091H0599; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0004096; F:catalase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 2.40.180.10; -; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR020835; Catalase-like_dom.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024711; Catalase_clade1/3.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR002226; Catalase_haem_BS.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   PANTHER; PTHR11465; PTHR11465; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF56634; SSF56634; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WF61.
DR   SWISS-2DPAGE; C6WF61.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Heme {ECO:0000256|PIRSR:PIRSR038928-2, ECO:0000256|RuleBase:RU000498};
KW   Hydrogen peroxide {ECO:0000256|RuleBase:RU000498};
KW   Iron {ECO:0000256|PIRSR:PIRSR038928-2, ECO:0000256|RuleBase:RU000498};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR038928-2,
KW   ECO:0000256|RuleBase:RU000498};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000498,
KW   ECO:0000313|EMBL:ACU34193.1};
KW   Peroxidase {ECO:0000256|RuleBase:RU000498,
KW   ECO:0000313|EMBL:ACU34193.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213}.
FT   DOMAIN        8    389       Catalase. {ECO:0000259|SMART:SM01060}.
FT   ACT_SITE     55     55       {ECO:0000256|PIRSR:PIRSR038928-1}.
FT   ACT_SITE    127    127       {ECO:0000256|PIRSR:PIRSR038928-1}.
FT   METAL       337    337       Iron (heme axial ligand).
FT                                {ECO:0000256|PIRSR:PIRSR038928-2}.
SQ   SEQUENCE   484 AA;  54309 MW;  1611F666F946223C CRC64;
     MTDARPTTNN AGIPIASDDH SLTLGPNGPI LLQDHYLIEK NAQFNRERVP ERVVHAKGGG
     AFGHFTTTAD VSRYTKAALF QPGVRTEALL RFSTVAGELG SPDTWRDPRG FALKLYTSQG
     NYDLVGNNTP VFFLRDPIKF PDFIRSQKRR VDTGRRDHDM QWDFWTLQPE TAHQVTWLMG
     DRGIPRTWRH QNGYGSHTYL WENAEGERHW VKYHFKTDQG IETLTADEAA RIAGEDADAH
     RADLWHAVER GEFPSWTLHV QVMPYEDAAG YRFNPFDLTK VWPQGDYPLI EVGKLVLDRN
     PSDHFAEIEQ AAFEPTNLVP GIGASPDKML LGRIFAYPDA HRYRIGANYA QLPVNRPKSR
     VDSYAKDGAM RYGNASDPVY APNSYGGPHA SAAVGSEATT SYGVEDAVVR SAYRLHPEDD
     DWGQAGTLVR EVMDDAQRDR LVETVVAHAG NGVSEPVLRR VFEYWRNIDK GVGDRIAAAF
     DGRS
//

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