(data stored in ACNUC7421 zone)

SWISSPROT: C6WF73_ACTMD

ID   C6WF73_ACTMD            Unreviewed;        97 AA.
AC   C6WF73;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   16-JAN-2019, entry version 44.
DE   RecName: Full=Transcriptional regulator WhiB {ECO:0000256|HAMAP-Rule:MF_01479};
GN   Name=whiB {ECO:0000256|HAMAP-Rule:MF_01479};
GN   OrderedLocusNames=Amir_0236 {ECO:0000313|EMBL:ACU34205.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34205.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34205.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- FUNCTION: Acts as a transcriptional regulator. Probably redox-
CC       responsive. The apo- but not holo-form probably binds DNA.
CC       {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01479};
CC       Note=Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation
CC       of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
CC       {ECO:0000256|HAMAP-Rule:MF_01479};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- PTM: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
CC       {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- PTM: Upon Fe-S cluster removal intramolecular disulfide bonds are
CC       formed. {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- SIMILARITY: Belongs to the WhiB family. {ECO:0000256|HAMAP-
CC       Rule:MF_01479}.
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DR   EMBL; CP001630; ACU34205.1; -; Genomic_DNA.
DR   RefSeq; WP_012782868.1; NC_013093.1.
DR   STRING; 446462.Amir_0236; -.
DR   EnsemblBacteria; ACU34205; ACU34205; Amir_0236.
DR   KEGG; ami:Amir_0236; -.
DR   eggNOG; ENOG4105N0U; Bacteria.
DR   eggNOG; ENOG4111W0R; LUCA.
DR   HOGENOM; HOG000247629; -.
DR   KO; K18955; -.
DR   OMA; FAAQRKH; -.
DR   OrthoDB; 1929976at2; -.
DR   BioCyc; AMIR446462:G1GEY-246-MONOMER; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0035731; F:dinitrosyl-iron complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01479; WhiB; 1.
DR   InterPro; IPR034768; 4FE4S_WBL.
DR   InterPro; IPR003482; Whib.
DR   PANTHER; PTHR38839; PTHR38839; 1.
DR   Pfam; PF02467; Whib; 1.
DR   PROSITE; PS51674; 4FE4S_WBL; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WF73.
DR   SWISS-2DPAGE; C6WF73.
KW   4Fe-4S {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Disulfide bond {ECO:0000256|HAMAP-Rule:MF_01479};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Iron {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Iron-sulfur {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   DOMAIN       12     68       4Fe-4S Wbl-type. {ECO:0000259|PROSITE:
FT                                PS51674}.
FT   METAL        13     13       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        13     13       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        35     35       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        35     35       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        38     38       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        38     38       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        44     44       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        44     44       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
SQ   SEQUENCE   97 AA;  11077 MW;  4918E7F42D02E6C3 CRC64;
     MQQQGDWRIK AACRDGEPDQ LFVRGAEQRK VKVVCLGCPV RTECLAEALD NRIEFGVWGG
     MTERERRALL KRRPDVTSWL ELLDSARTDH YEESAAG
//

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