(data stored in ACNUC7421 zone)

SWISSPROT: C6WGF9_ACTMD

ID   C6WGF9_ACTMD            Unreviewed;       555 AA.
AC   C6WGF9;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 46.
DE   SubName: Full=Drug resistance transporter, EmrB/QacA subfamily {ECO:0000313|EMBL:ACU34275.1};
GN   OrderedLocusNames=Amir_0306 {ECO:0000313|EMBL:ACU34275.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34275.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34275.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; CP001630; ACU34275.1; -; Genomic_DNA.
DR   RefSeq; WP_012782938.1; NC_013093.1.
DR   STRING; 446462.Amir_0306; -.
DR   EnsemblBacteria; ACU34275; ACU34275; Amir_0306.
DR   KEGG; ami:Amir_0306; -.
DR   eggNOG; ENOG4105C0R; Bacteria.
DR   eggNOG; ENOG410XNN3; LUCA.
DR   HOGENOM; HOG000239126; -.
DR   OMA; SGLVVHW; -.
DR   OrthoDB; POG091H07IV; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005215; F:transporter activity; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; Drug-R_transpt_efflux_EmrB.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR   Pfam; PF07690; MFS_1; 1.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; SSF103473; 3.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WGF9.
DR   SWISS-2DPAGE; C6WGF9.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     23     48       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     60     79       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     91    110       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    116    137       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    149    173       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    185    206       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    218    235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    241    265       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    286    310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    316    337       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    349    368       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    380    401       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    422    440       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    509    528       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       26    533       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   555 AA;  58690 MW;  8A998393D625A626 CRC64;
     MSETTTQAGA TPPGAALLTH RQILTILSGL LMGMFLAALD QMIVATAMKT IADHLNGQTI
     QAWATTAYLI TSTITTPLYG KLSDIYGRKP MYLTAISMFL VGSLLCGIAN SMYELAAFRA
     VQGLGAGGLM SLAFAILADI TSPRERSRYA GYFMAVFGVA SVAGPVVGGL FAGMDHFLGF
     AGWRWVFLVN VPIALAALAV VAKVLNIPHQ RVDHRVDFLG AITLTVGLVP LLIVAEQGRE
     WGWGSATAIA MYVVGVLGLV AFVWAEKRAG DEALLPLRLF RKQTFALGNT INFVLGAGMF
     GGMVSIPLYL QIVQGHSATT AGLMMLPMTL GIMTAAGTSG KITSKTGRYK VFPVVGFAVM
     TASLFLFSTV GVDTATWQPM ALMFTMGLGL GLCMQTLLIA IQNDAEPRDM GVATSSATFF
     RQIGGTVGAA VFLSVLFSTV GDKIGEALRS AMGTDAFRAA LARPENQAFA QQLQSGGASA
     DLNNTEFLSK LDPVLARPFL EGFSSAIDTV FFVGALVTLV GFAIVWFLRE VPLSDRSGLE
     RSKDEADAAS TIALH
//

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