(data stored in ACNUC7421 zone)

SWISSPROT: C6WHY1_ACTMD

ID   C6WHY1_ACTMD            Unreviewed;       467 AA.
AC   C6WHY1;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   05-JUL-2017, entry version 55.
DE   SubName: Full=Malate dehydrogenase (Oxaloacetate-decarboxylating) {ECO:0000313|EMBL:ACU34432.1};
DE            EC=1.1.1.38 {ECO:0000313|EMBL:ACU34432.1};
GN   OrderedLocusNames=Amir_0465 {ECO:0000313|EMBL:ACU34432.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34432.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34432.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|RuleBase:RU003427}.
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DR   EMBL; CP001630; ACU34432.1; -; Genomic_DNA.
DR   RefSeq; WP_012783095.1; NC_013093.1.
DR   ProteinModelPortal; C6WHY1; -.
DR   STRING; 446462.Amir_0465; -.
DR   EnsemblBacteria; ACU34432; ACU34432; Amir_0465.
DR   KEGG; ami:Amir_0465; -.
DR   eggNOG; ENOG4105C6K; Bacteria.
DR   eggNOG; COG0281; LUCA.
DR   HOGENOM; HOG000132447; -.
DR   KO; K00027; -.
DR   OMA; FRGMLDA; -.
DR   OrthoDB; POG091H02AU; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WHY1.
DR   SWISS-2DPAGE; C6WHY1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
KW   ECO:0000256|RuleBase:RU003427};
KW   Oxidoreductase {ECO:0000313|EMBL:ACU34432.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213}.
FT   DOMAIN       92    225       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      237    459       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE    113    113       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    168    168       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       210    210       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       211    211       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       236    236       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   467 AA;  48960 MW;  77C710BB28C29644 CRC64;
     MPVPGPGYSI TVRLEAPPSA SAAGDLTSAV GRAGGVITAF DVVESHNDRV IIDLTCNALS
     ANHAKDITDT LEQLPGIVVR KVSDRTFLVH LGGKIEISSK VPLRNRDDLS RAYTPGVARV
     CQAIAENPED ARRLTIKRNT VAVVTDGSAV LGLGNLGPAA ALPVMEGKAA LFKKFAGVDA
     WPVCLDTQDT EEIIRAVELI APVYGGINLE DIAAPRCFEI EARLREKLDI PVFHDDQHGT
     AIVVVGALRN ALRVVGKDIS ECKIVVCGVG AAGSAIIRLL LKQTPGDVVA VDVDGIVHRD
     RPGMDPNLAS VAESTNKENV SGRLHDALVG ADVFIGVSAP NLFGAEQVAT MNSDAIVFAL
     ANPDPEIDPM EAQKHAAVVA TGRSDFPNQI NNVLAFPGVF RGLLDANANT ITDEMLLAAA
     TAIADVVDGD RLNASFIVPS VFDTTVAPAV AEAVRKVASE LKAAERA
//

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