(data stored in ACNUC7421 zone)

SWISSPROT: C6WI18_ACTMD

ID   C6WI18_ACTMD            Unreviewed;       281 AA.
AC   C6WI18;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   07-JUN-2017, entry version 42.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000256|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000256|HAMAP-Rule:MF_01384};
GN   OrderedLocusNames=Amir_0502 {ECO:0000313|EMBL:ACU34469.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34469.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34469.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter.
CC       {ECO:0000256|HAMAP-Rule:MF_01384, ECO:0000256|SAAS:SAAS00390955}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing
CC       metallocenter of UreC. The UreE protein probably delivers the
CC       nickel. {ECO:0000256|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01384,
CC       ECO:0000256|SAAS:SAAS00101009}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000256|HAMAP-
CC       Rule:MF_01384, ECO:0000256|SAAS:SAAS00577332}.
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DR   EMBL; CP001630; ACU34469.1; -; Genomic_DNA.
DR   RefSeq; WP_012783132.1; NC_013093.1.
DR   STRING; 446462.Amir_0502; -.
DR   EnsemblBacteria; ACU34469; ACU34469; Amir_0502.
DR   KEGG; ami:Amir_0502; -.
DR   eggNOG; ENOG4105MT3; Bacteria.
DR   eggNOG; ENOG4111V7G; LUCA.
DR   HOGENOM; HOG000049644; -.
DR   KO; K03190; -.
DR   OMA; RTENDHA; -.
DR   OrthoDB; POG091H0G6E; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WI18.
DR   SWISS-2DPAGE; C6WI18.
KW   Chaperone {ECO:0000256|HAMAP-Rule:MF_01384,
KW   ECO:0000256|SAAS:SAAS00468268};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01384,
KW   ECO:0000256|SAAS:SAAS00101006};
KW   Nickel insertion {ECO:0000256|HAMAP-Rule:MF_01384,
KW   ECO:0000256|SAAS:SAAS00101004};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213}.
SQ   SEQUENCE   281 AA;  29363 MW;  D48A963C17F4DA75 CRC64;
     MKAFARLVAE RNPNGRTVIR EMRSATPLTL VPARGARSDA HALVHLVSSI TAPLGGDELE
     LRITVGPGAA LVLRGVAATV ALPGHRPGGS RSRVLLEVAE GGSVEHLPEP TVVTARADHE
     AVLEAELAEG ARLRAREVLV LGRLGERPGR LTTTTSVRRG GPLLRQSLTI GDERGGPDTV
     DTSPAGLAGR RVIGAEVLCW GEDPAGPVSG DWWSLVPLAR GGSLATALGD TVIEVERALT
     GACGSHPGSS ELLTRSRARF RADGHTLRVR SHRPGGSAQD R
//

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