(data stored in ACNUC7421 zone)

SWISSPROT: C6WI44_ACTMD

ID   C6WI44_ACTMD            Unreviewed;       437 AA.
AC   C6WI44;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   05-JUL-2017, entry version 62.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
GN   OrderedLocusNames=Amir_0528 {ECO:0000313|EMBL:ACU34495.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU34495.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU34495.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + oxaloacetate = citrate +
CC       CoA. {ECO:0000256|RuleBase:RU003370}.
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       isocitrate from oxaloacetate: step 1/2.
CC       {ECO:0000256|RuleBase:RU003370}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003406}.
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DR   EMBL; CP001630; ACU34495.1; -; Genomic_DNA.
DR   RefSeq; WP_012783158.1; NC_013093.1.
DR   STRING; 446462.Amir_0528; -.
DR   EnsemblBacteria; ACU34495; ACU34495; Amir_0528.
DR   KEGG; ami:Amir_0528; -.
DR   eggNOG; ENOG4105BZN; Bacteria.
DR   eggNOG; COG0372; LUCA.
DR   HOGENOM; HOG000021224; -.
DR   KO; K01647; -.
DR   OMA; TVGWCAQ; -.
DR   OrthoDB; POG091H00T5; -.
DR   UniPathway; UPA00223; UER00717.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.230.10; -; 1.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR010953; Citrate_synthase_typ-I.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   TIGRFAMs; TIGR01798; cit_synth_I; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; C6WI44.
DR   SWISS-2DPAGE; C6WI44.
KW   Acyltransferase {ECO:0000313|EMBL:ACU34495.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001369,
KW   ECO:0000256|RuleBase:RU003370, ECO:0000313|EMBL:ACU34495.1};
KW   Tricarboxylic acid cycle {ECO:0000256|RuleBase:RU003370}.
FT   ACT_SITE    315    315       {ECO:0000256|PIRSR:PIRSR001369-1}.
FT   ACT_SITE    372    372       {ECO:0000256|PIRSR:PIRSR001369-1}.
SQ   SEQUENCE   437 AA;  48245 MW;  38EA0729784B615E CRC64;
     MSDATTAPND PRTVALRHDG GEHEMQLVRA TEGASGIDLG KLLAKTGLVT LDSGFVNTAS
     CSSEITYIDG DAGILRYRGY PIEQLAEKSN FLEVSYLLIN GELPTEAQLA DFSSKISRHT
     LLHEDLKRFF DGFPRDAHPM PVLSSAVSAL STFYQDSLNP FDTKQVEMST IRLLAKVPTI
     AAYAYKKSVG QPFLYPDNSL GLVENFLRMT FGFPAEPYDV DPDLVKALDL LFILHADHEQ
     NCSTSTVRLV GSSEANLFAS ISAGINALFG PLHGGANSAV LEMLEKIRNE GGDVASFVKK
     VKNKEDGVRL MGFGHRVYKN YDPRAAIIKR TADDILGKLG GDDQLLDIAK ALEEAALSDD
     YFVERKLYPN VDFYTGLIYR AMGFPTKFFT VLFALGRLPG WIAHWREMIN DPATKIGRPR
     QIYIGSPARD FVPMTER
//

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