(data stored in ACNUC7421 zone)

SWISSPROT: C7QH82_CATAD

ID   C7QH82_CATAD            Unreviewed;       433 AA.
AC   C7QH82;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   05-JUL-2017, entry version 56.
DE   RecName: Full=Na(+)/H(+) antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
DE   AltName: Full=Sodium/proton antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   Name=nhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   OrderedLocusNames=Caci_0066 {ECO:0000313|EMBL:ACU69021.1};
OS   Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC
OS   102108 / JCM 14897).
OC   Bacteria; Actinobacteria; Catenulisporales; Catenulisporaceae;
OC   Catenulispora.
OX   NCBI_TaxID=479433 {ECO:0000313|EMBL:ACU69021.1, ECO:0000313|Proteomes:UP000000851};
RN   [1] {ECO:0000313|EMBL:ACU69021.1, ECO:0000313|Proteomes:UP000000851}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897
RC   {ECO:0000313|Proteomes:UP000000851};
RX   PubMed=21304647;
RA   Copeland A., Lapidus A., Glavina Del Rio T., Nolan M., Lucas S.,
RA   Chen F., Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S.,
RA   Mikhailova N., Pati A., Ivanova N., Mavromatis K., Chen A.,
RA   Palaniappan K., Chain P., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Chertkov O., Brettin T., Detter J.C., Han C., Ali Z.,
RA   Tindall B.J., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Catenulispora acidiphila type strain (ID
RT   139908).";
RL   Stand. Genomic Sci. 1:119-125(2009).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000256|HAMAP-Rule:MF_01844,
CC       ECO:0000256|SAAS:SAAS00693862}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01844}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01844}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000256|HAMAP-Rule:MF_01844,
CC       ECO:0000256|SAAS:SAAS00693876}.
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DR   EMBL; CP001700; ACU69021.1; -; Genomic_DNA.
DR   RefSeq; WP_012784316.1; NC_013131.1.
DR   EnsemblBacteria; ACU69021; ACU69021; Caci_0066.
DR   KEGG; cai:Caci_0066; -.
DR   eggNOG; ENOG4105DRC; Bacteria.
DR   eggNOG; COG3004; LUCA.
DR   HOGENOM; HOG000218489; -.
DR   KO; K03313; -.
DR   OMA; LTWTHIT; -.
DR   OrthoDB; POG091H05CU; -.
DR   Proteomes; UP000000851; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   HAMAP; MF_01844; NhaA; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom.
DR   InterPro; IPR004670; NhaA.
DR   PANTHER; PTHR30341:SF2; PTHR30341:SF2; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   TIGRFAMs; TIGR00773; NhaA; 1.
PE   3: Inferred from homology;
DR   PRODOM; C7QH82.
DR   SWISS-2DPAGE; C7QH82.
KW   Antiport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693867};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693865};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000851};
KW   Ion transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693875};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693879};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000851};
KW   Sodium {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693859};
KW   Sodium transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693872};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693873};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693863};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693869}.
FT   TRANSMEM     27     50       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    112    132       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    144    162       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    174    193       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    199    215       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    285    304       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    316    338       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    359    378       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    390    407       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
SQ   SEQUENCE   433 AA;  45948 MW;  36455013D17AB9B3 CRC64;
     MTPPDRPASP SRVFARLKRI ERRHVAAVLR TETVGGALLI AFALLGLLWA NSPWRASYDT
     VKNTVVGPHL WHLDLSLADW AADFLLAFFF LVAGIELKHE LQAGELSNPR AAALPVVSAL
     CGMIVPIGVY LAVSAGHTNA GEGWAVPTAT DIAFALAVLA VVGQNLPSAL RAFLLTLAVV
     DDLGAIIIIA IAYTDSIDTG ALVIAAVLLL AFYVVQRMRI TSLWLNVPLG LAIWIAVHAS
     GVHATVAGVA IGLMLRGRRH GDSDEDHDDE LQSPAEKVQW RLQPFSAGFC VPVFAIMSAG
     VYVGGKTLGS LVSDQIPLAI AAGLFIGKAV GVFGGAYLTA RFTRAELSDE LQWRDIAAVS
     ALTGVGFTVS LLIAELGFSD SPDVLNLAKG GVLLGSLASA LFAVVLLRRR DRFYDQLCTA
     EESEDSELVL GRE
//

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