(data stored in ACNUC7421 zone)

SWISSPROT: C7QJ01_CATAD

ID   C7QJ01_CATAD            Unreviewed;      1182 AA.
AC   C7QJ01;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   07-JUN-2017, entry version 62.
DE   RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE            Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE            EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN   Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN   OrderedLocusNames=Caci_0188 {ECO:0000313|EMBL:ACU69143.1};
OS   Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC
OS   102108 / JCM 14897).
OC   Bacteria; Actinobacteria; Catenulisporales; Catenulisporaceae;
OC   Catenulispora.
OX   NCBI_TaxID=479433 {ECO:0000313|EMBL:ACU69143.1, ECO:0000313|Proteomes:UP000000851};
RN   [1] {ECO:0000313|EMBL:ACU69143.1, ECO:0000313|Proteomes:UP000000851}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897
RC   {ECO:0000313|Proteomes:UP000000851};
RX   PubMed=21304647;
RA   Copeland A., Lapidus A., Glavina Del Rio T., Nolan M., Lucas S.,
RA   Chen F., Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S.,
RA   Mikhailova N., Pati A., Ivanova N., Mavromatis K., Chen A.,
RA   Palaniappan K., Chain P., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Chertkov O., Brettin T., Detter J.C., Han C., Ali Z.,
RA   Tindall B.J., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Catenulispora acidiphila type strain (ID
RT   139908).";
RL   Stand. Genomic Sci. 1:119-125(2009).
CC   -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC       polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC       release of RNAP and its truncated transcript from the DNA, and
CC       recruitment of nucleotide excision repair machinery to the damaged
CC       site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the helicase
CC       family. RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR   EMBL; CP001700; ACU69143.1; -; Genomic_DNA.
DR   RefSeq; WP_012784438.1; NC_013131.1.
DR   ProteinModelPortal; C7QJ01; -.
DR   STRING; 479433.Caci_0188; -.
DR   EnsemblBacteria; ACU69143; ACU69143; Caci_0188.
DR   KEGG; cai:Caci_0188; -.
DR   eggNOG; ENOG4108JA2; Bacteria.
DR   eggNOG; COG1197; LUCA.
DR   HOGENOM; HOG000216591; -.
DR   KO; K03723; -.
DR   OMA; LDIPRVN; -.
DR   OrthoDB; POG091H025E; -.
DR   Proteomes; UP000000851; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00969; TRCF; 1.
DR   InterPro; IPR003711; CarD-like/TRCF_domain.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR004576; Mfd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005118; TRCF_C.
DR   Pfam; PF02559; CarD_CdnL_TRCF; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF03461; TRCF; 1.
DR   SMART; SM01058; CarD_TRCF; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00982; TRCF; 1.
DR   SUPFAM; SSF141259; SSF141259; 1.
DR   SUPFAM; SSF52540; SSF52540; 4.
DR   TIGRFAMs; TIGR00580; mfd; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
DR   PRODOM; C7QJ01.
DR   SWISS-2DPAGE; C7QJ01.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00969};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000851};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00969};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00969};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00969};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00969};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00969};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000851}.
FT   DOMAIN      648    809       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      827    984       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
SQ   SEQUENCE   1182 AA;  129475 MW;  37F86AF60617277B CRC64;
     MSLSGLLDAV SADPGVAALL EAAATAGRTS FDLAAPRSVR PFALAALARA QGPAGRPVLA
     VTATGREAED LVAALRGLLD PETVVDFPSW ETLPHERLSP RSDTVGRRLA VLRRLVHPDA
     ATEGAGALKV VVAPIRSVLQ PQVKGLADLV PVAARTGAEI DLDDLVNRLA AAAYTRTDLV
     DKRGEFAVRG GIVDVFPPTE EHPLRLEFWG DQIEEIRYFK VADQRSLEVA EHGLWAPPCR
     ELLLTDEVRK RAAALMEDHP ELADILGKVS EGIGVEGMES LAPVLVDDME LLIDLLPAGS
     PIVLCDPERV RTRAADLAAT SAEFLDASWA ATAGGGQTPI DLGAASLKDL ASVREHAITL
     GLPWWSLTPF APDLELLPEE DATEISEIHD TEQYGGDTGR ALADVRARIS EGWRVVLVTQ
     GHGSADRLVE VLKGADIGAR YVPELDTVPE PALATVATAS IEHGFIAADL KLWVITEQDV
     SGQRTATKDM SRMPSRRRNV IDPLQLKAGD PVVHEQHGVG RYVEMAQRTV AGATREYLVI
     EYAAAKRGQP GDRLFVPTDQ LDQVTKYVGG EAPSLHRLGG ADWQKAKSRA RKAVKQIAGD
     LVKLYSARMA APGHAFAADT PWQRELEDAF PYVETPDQLA CIDEVKSDME KPVPMDRLIC
     GDVGYGKTEI AVRAAFKAVQ DGKQVAVLVP TTLLVQQHFS TFAERYAQFP VTLKGLSRFQ
     TDKEAAEVLR GVADGSVDVV IGTHRLLANS VKFKRLGLVI VDEEQRFGVE HKEQLKQARA
     NVDVLTMSAT PIPRTLEMAV TGIREMSTIQ TPPEERHPVL TFVGPYEERQ ISAAIRRELL
     REGQAFYIHN RVESIDRAAS RLRALVPEAR IATAHGQMNE HVLEKLIVDF WNKEYDVLVC
     TTIVESGIDI TNANTLIVER ADNFGLSQLH QLRGRVGRGR ERAYSYFTYP PEKPLTETAH
     ERLATIAQHT DLGAGMYVAM KDLEIRGAGN LLGGEQSGHI EGVGFDLYIR MVGEAVEEYR
     AQAEGREVEE QVEIRVDLPV DAHLPHDYIP GERLRLEAYK RIAGATTHEE LAEVRQEFTD
     RYGRFPQPVE NLLAVAAFRI DARAAGLTEV AVQGNFVKFG PVKLRESQEM RLLRLFPKTL
     VKAATDTMLV PKPMTARIGG QPLRDQELLG WARDLIDAVL KM
//

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