(data stored in ACNUC7421 zone)

SWISSPROT: C7QJ64_CATAD

ID   C7QJ64_CATAD            Unreviewed;       556 AA.
AC   C7QJ64;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   30-AUG-2017, entry version 62.
DE   RecName: Full=Urocanate hydratase {ECO:0000256|HAMAP-Rule:MF_00577, ECO:0000256|SAAS:SAAS00693702};
DE            Short=Urocanase {ECO:0000256|HAMAP-Rule:MF_00577};
DE            EC=4.2.1.49 {ECO:0000256|HAMAP-Rule:MF_00577, ECO:0000256|SAAS:SAAS00693702};
DE   AltName: Full=Imidazolonepropionate hydrolase {ECO:0000256|HAMAP-Rule:MF_00577};
GN   Name=hutU {ECO:0000256|HAMAP-Rule:MF_00577};
GN   OrderedLocusNames=Caci_0253 {ECO:0000313|EMBL:ACU69206.1};
OS   Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC
OS   102108 / JCM 14897).
OC   Bacteria; Actinobacteria; Catenulisporales; Catenulisporaceae;
OC   Catenulispora.
OX   NCBI_TaxID=479433 {ECO:0000313|EMBL:ACU69206.1, ECO:0000313|Proteomes:UP000000851};
RN   [1] {ECO:0000313|EMBL:ACU69206.1, ECO:0000313|Proteomes:UP000000851}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897
RC   {ECO:0000313|Proteomes:UP000000851};
RX   PubMed=21304647;
RA   Copeland A., Lapidus A., Glavina Del Rio T., Nolan M., Lucas S.,
RA   Chen F., Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S.,
RA   Mikhailova N., Pati A., Ivanova N., Mavromatis K., Chen A.,
RA   Palaniappan K., Chain P., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Chertkov O., Brettin T., Detter J.C., Han C., Ali Z.,
RA   Tindall B.J., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Catenulispora acidiphila type strain (ID
RT   139908).";
RL   Stand. Genomic Sci. 1:119-125(2009).
CC   -!- CATALYTIC ACTIVITY: 3-(5-oxo-4,5-dihydro-3H-imidazol-4-
CC       yl)propanoate = urocanate + H(2)O. {ECO:0000256|HAMAP-
CC       Rule:MF_00577, ECO:0000256|SAAS:SAAS00693674}.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00577};
CC       Note=Binds 1 NAD(+) per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00577};
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
CC       {ECO:0000256|HAMAP-Rule:MF_00577, ECO:0000256|SAAS:SAAS00693692}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00577}.
CC   -!- SIMILARITY: Belongs to the urocanase family. {ECO:0000256|HAMAP-
CC       Rule:MF_00577, ECO:0000256|SAAS:SAAS00693689}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001700; ACU69206.1; -; Genomic_DNA.
DR   RefSeq; WP_012784501.1; NC_013131.1.
DR   STRING; 479433.Caci_0253; -.
DR   EnsemblBacteria; ACU69206; ACU69206; Caci_0253.
DR   KEGG; cai:Caci_0253; -.
DR   eggNOG; ENOG4105CGP; Bacteria.
DR   eggNOG; COG2987; LUCA.
DR   HOGENOM; HOG000237606; -.
DR   KO; K01712; -.
DR   OMA; VSFHHGG; -.
DR   OrthoDB; POG091H0CXO; -.
DR   UniPathway; UPA00379; UER00550.
DR   Proteomes; UP000000851; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016153; F:urocanate hydratase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00577; HutU; 1.
DR   InterPro; IPR023637; Urocanase.
DR   InterPro; IPR035401; Urocanase_C.
DR   InterPro; IPR023636; Urocanase_CS.
DR   InterPro; IPR035400; Urocanase_N.
DR   InterPro; IPR035085; Urocanase_Rossmann-like.
DR   PANTHER; PTHR12216; PTHR12216; 1.
DR   Pfam; PF01175; Urocanase; 1.
DR   Pfam; PF17392; Urocanase_C; 1.
DR   Pfam; PF17391; Urocanase_N; 1.
DR   PIRSF; PIRSF001423; Urocanate_hydrat; 1.
DR   SUPFAM; SSF111326; SSF111326; 1.
DR   TIGRFAMs; TIGR01228; hutU; 1.
DR   PROSITE; PS01233; UROCANASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; C7QJ64.
DR   SWISS-2DPAGE; C7QJ64.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000851};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00577};
KW   Histidine metabolism {ECO:0000256|HAMAP-Rule:MF_00577,
KW   ECO:0000256|SAAS:SAAS00693681};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00577, ECO:0000256|SAAS:SAAS00693676,
KW   ECO:0000313|EMBL:ACU69206.1};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_00577, ECO:0000256|SAAS:SAAS00693683};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000851}.
FT   DOMAIN       10    136       Urocanase_N. {ECO:0000259|Pfam:PF17391}.
FT   DOMAIN      139    346       Urocanase. {ECO:0000259|Pfam:PF01175}.
FT   DOMAIN      349    543       Urocanase_C. {ECO:0000259|Pfam:PF17392}.
FT   ACT_SITE    408    408       {ECO:0000256|HAMAP-Rule:MF_00577}.
SQ   SEQUENCE   556 AA;  60086 MW;  B9C6C069B3CF5DB8 CRC64;
     MTATSGPRPV RAARGTSITA QGWQQEAALR MLMNNLDPEV AEHPDELVVY GGTGKAARNW
     PSFDAMVRTL QTLKNDETML VQSGKPVGVM QTHEWAPRVL LANSNLVGDW ANWEEFRRLD
     ALGLTMYGQM TAGSWIYIGT QGILQGTYET FAAVAAKKFN DTLAGTITLT AGLGGMGGAQ
     PLAVTMNGGV AICVDCDERS IDRRVEHRYL DVKANSLDHA LQLATEARDK REALSIGVLG
     NAAELVPRLL AMDAPIDIVT DQTSAHDPLA YLPLGMDFHD MKQFAKDKPA EFTQRARESM
     AKHVEAMVGF QDKGAEVFDY GNSIRGEAQL AGYTRAFDFP GFVPAYIRPL FCEGKGPFRW
     AALSGEASDI AKTDKAILEL FPENESLARW IKMAGERVHF QGLPARICWL GYGERDKAGA
     RFNDMVADGT LAAPIVIGRD HLDAGSVASP YRETEAMADG SDAIADWPLL NAMVNVASGA
     SWVSIHHGGG VGMGRSIHAG QVTVADGTKL AGEKVRRVLT NDPGMGVIRH VDAGYDRADE
     VADERGVRVP MREGDA
//

If you have problems or comments...

PBIL Back to PBIL home page