(data stored in ACNUC7421 zone)

SWISSPROT: C8VVD6_DESAS

ID   C8VVD6_DESAS            Unreviewed;       432 AA.
AC   C8VVD6;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   08-MAY-2019, entry version 47.
DE   RecName: Full=Phenylacetate-coenzyme A ligase {ECO:0000256|PIRNR:PIRNR006444};
DE            EC=6.2.1.30 {ECO:0000256|PIRNR:PIRNR006444};
DE   AltName: Full=Phenylacetyl-CoA ligase {ECO:0000256|PIRNR:PIRNR006444};
GN   OrderedLocusNames=Dtox_0042 {ECO:0000313|EMBL:ACV61006.1};
OS   Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM
OS   B-1644) (Desulfofarcimen acetoxidans).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Peptococcaceae;
OC   Desulfofarcimen.
OX   NCBI_TaxID=485916 {ECO:0000313|EMBL:ACV61006.1, ECO:0000313|Proteomes:UP000002217};
RN   [1] {ECO:0000313|EMBL:ACV61006.1, ECO:0000313|Proteomes:UP000002217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49208 / DSM 771 / VKM B-1644
RC   {ECO:0000313|Proteomes:UP000002217};
RX   PubMed=21304664; DOI=10.4056/sigs.39508;
RA   Spring S., Lapidus A., Schroder M., Gleim D., Sims D., Meincke L.,
RA   Glavina Del Rio T., Tice H., Copeland A., Cheng J.F., Lucas S.,
RA   Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S., Ivanova N.,
RA   Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P., Saunders E.,
RA   Brettin T., Detter J.C., Goker M., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Han C.;
RT   "Complete genome sequence of Desulfotomaculum acetoxidans type strain
RT   (5575).";
RL   Stand. Genomic Sci. 1:242-253(2009).
CC   -!- FUNCTION: Catalyzes the activation of phenylacetic acid (PA) to
CC       phenylacetyl-CoA (PA-CoA). {ECO:0000256|PIRNR:PIRNR006444}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-phenylacetate + ATP + CoA = AMP + diphosphate +
CC         phenylacetyl-CoA; Xref=Rhea:RHEA:20956, ChEBI:CHEBI:18401,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57390, ChEBI:CHEBI:456215; EC=6.2.1.30;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006444};
CC   -!- PATHWAY: Aromatic compound metabolism; phenylacetate degradation.
CC       {ECO:0000256|PIRNR:PIRNR006444}.
CC   -!- SIMILARITY: Belongs to the phenylacetyl-CoA ligase family.
CC       {ECO:0000256|PIRNR:PIRNR006444}.
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DR   EMBL; CP001720; ACV61006.1; -; Genomic_DNA.
DR   RefSeq; WP_012813458.1; NC_013216.1.
DR   STRING; 485916.Dtox_0042; -.
DR   EnsemblBacteria; ACV61006; ACV61006; Dtox_0042.
DR   KEGG; dae:Dtox_0042; -.
DR   eggNOG; ENOG4105DZS; Bacteria.
DR   eggNOG; COG1541; LUCA.
DR   HOGENOM; HOG000197614; -.
DR   KO; K01912; -.
DR   OMA; YDSYGLS; -.
DR   OrthoDB; 839891at2; -.
DR   BioCyc; DACE485916:G1GFV-46-MONOMER; -.
DR   UniPathway; UPA00930; -.
DR   Proteomes; UP000002217; Chromosome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0047475; F:phenylacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0010124; P:phenylacetate catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR028154; AMP-dep_Lig_C.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; AMP-dep_Synthh-like_sf.
DR   InterPro; IPR011880; PA_CoA_ligase.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF14535; AMP-binding_C_2; 1.
DR   PIRSF; PIRSF006444; PaaK; 1.
PE   3: Inferred from homology;
DR   PRODOM; C8VVD6.
DR   SWISS-2DPAGE; C8VVD6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002217};
KW   Ligase {ECO:0000256|PIRNR:PIRNR006444, ECO:0000313|EMBL:ACV61006.1};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR006444};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002217}.
FT   DOMAIN       90    285       AMP-binding. {ECO:0000259|Pfam:PF00501}.
FT   DOMAIN      334    430       AMP-binding_C_2. {ECO:0000259|Pfam:
FT                                PF14535}.
SQ   SEQUENCE   432 AA;  48104 MW;  60D7A4D92C708A74 CRC64;
     MIWDPDVECM DREAMQSLQL QRLQETVRRV FDRIPFYRES FTAAGVKPAD IQKLKDIEKL
     PFTVKNDLRD NYPYGLFAVP LQKIIRLHAS SGTTGKPIVV GYTKKDIETW TELVARLVTM
     AGVTSDDVAQ ITFGYGLFTG AFGLHYGLER VGATIVPAST GNTEKQVMLM QDFGTTALIG
     TPSYVLHLAE SVAALGIDPS EMKLRVGMFG SEVWSESMRA QIERAWGIKA TDNYGLSEVM
     GPGVSGECSF ANGLHIAEDH FLLEIIDPDT GEGLDYGQEG EVVITTLTKE GIPLIRYRTR
     DISVINTAPC ECGRSSARLR KIGGRTDDML IISGVNVFPS QIESVIMNIE GVAPHYQIVV
     GKKGYLDYLE VQVEIAQERF TGNFKDLEEL EQKIRRRLHN VLSISPRVRL MEPLSIERSV
     GKAKRIIDNR PK
//

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