(data stored in ACNUC7421 zone)

SWISSPROT: C8VVG1_DESAS

ID   C8VVG1_DESAS            Unreviewed;       355 AA.
AC   C8VVG1;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   08-MAY-2019, entry version 54.
DE   RecName: Full=Peptide chain release factor 1 {ECO:0000256|HAMAP-Rule:MF_00093};
DE            Short=RF-1 {ECO:0000256|HAMAP-Rule:MF_00093};
GN   Name=prfA {ECO:0000256|HAMAP-Rule:MF_00093};
GN   OrderedLocusNames=Dtox_0064 {ECO:0000313|EMBL:ACV61027.1};
OS   Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM
OS   B-1644) (Desulfofarcimen acetoxidans).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Peptococcaceae;
OC   Desulfofarcimen.
OX   NCBI_TaxID=485916 {ECO:0000313|EMBL:ACV61027.1, ECO:0000313|Proteomes:UP000002217};
RN   [1] {ECO:0000313|EMBL:ACV61027.1, ECO:0000313|Proteomes:UP000002217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49208 / DSM 771 / VKM B-1644
RC   {ECO:0000313|Proteomes:UP000002217};
RX   PubMed=21304664; DOI=10.4056/sigs.39508;
RA   Spring S., Lapidus A., Schroder M., Gleim D., Sims D., Meincke L.,
RA   Glavina Del Rio T., Tice H., Copeland A., Cheng J.F., Lucas S.,
RA   Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S., Ivanova N.,
RA   Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P., Saunders E.,
RA   Brettin T., Detter J.C., Goker M., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Han C.;
RT   "Complete genome sequence of Desulfotomaculum acetoxidans type strain
RT   (5575).";
RL   Stand. Genomic Sci. 1:242-253(2009).
CC   -!- FUNCTION: Peptide chain release factor 1 directs the termination
CC       of translation in response to the peptide chain termination codons
CC       UAG and UAA. {ECO:0000256|HAMAP-Rule:MF_00093}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00093}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF1. {ECO:0000256|HAMAP-Rule:MF_00093}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release
CC       factor family. {ECO:0000256|HAMAP-Rule:MF_00093}.
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DR   EMBL; CP001720; ACV61027.1; -; Genomic_DNA.
DR   RefSeq; WP_012813479.1; NC_013216.1.
DR   STRING; 485916.Dtox_0064; -.
DR   EnsemblBacteria; ACV61027; ACV61027; Dtox_0064.
DR   KEGG; dae:Dtox_0064; -.
DR   eggNOG; ENOG4105C8K; Bacteria.
DR   eggNOG; COG0216; LUCA.
DR   HOGENOM; HOG000074815; -.
DR   KO; K02835; -.
DR   OMA; DLFRMYQ; -.
DR   OrthoDB; 928964at2; -.
DR   BioCyc; DACE485916:G1GFV-68-MONOMER; -.
DR   Proteomes; UP000002217; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00093; Rel_fac_1; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I_II.
DR   InterPro; IPR004373; PrfA.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   TIGRFAMs; TIGR00019; prfA; 1.
PE   3: Inferred from homology;
DR   PRODOM; C8VVG1.
DR   SWISS-2DPAGE; C8VVG1.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002217};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00093};
KW   Methylation {ECO:0000256|HAMAP-Rule:MF_00093};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00093};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002217}.
FT   DOMAIN       63    177       PCRF. {ECO:0000259|SMART:SM00937}.
FT   COILED       44     94       {ECO:0000256|SAM:Coils}.
FT   MOD_RES     233    233       N5-methylglutamine. {ECO:0000256|HAMAP-
FT                                Rule:MF_00093}.
SQ   SEQUENCE   355 AA;  40463 MW;  B7F2F558679D4951 CRC64;
     MFERLQKIEE RYEELGDLMG DPEVMADHSR WQQYVKAHAD MQDIVNVYRE YRQLDQEVSD
     ARELLKDKLD EDFREMVELE LEELSEKKEE LVQKLKLLLL PKDPNDDKNV ILEVRAGTGG
     EEAALFAGDL FRMYTRYAEK QGWRTEVLDA NYTDIGGFKE VVCMIEGKGA YSRLKFESGV
     HRVQRVPSTE SGGRIHTSAA TVAVLPEAEE VEIDINPNDL RIDVFCSTGP GGQSVNTTQS
     AVRITHLPSG LVVSCQDEKS QHKNKDKAMR VLRARLKDLA ESEQRSELAS TRKSMVGSGD
     RSERIRTYNF PQNRITDHRI GLTTHRMPAV LMGEMDEIIE ALITTDQADR LRSTE
//

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