(data stored in ACNUC7421 zone)

SWISSPROT: D1CDD8_THET1

ID   D1CDD8_THET1            Unreviewed;       415 AA.
AC   D1CDD8;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   08-MAY-2019, entry version 62.
DE   RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 2 {ECO:0000256|PIRNR:PIRNR000447};
DE            EC=2.3.1.179 {ECO:0000256|PIRNR:PIRNR000447};
GN   OrderedLocusNames=Tter_0021 {ECO:0000313|EMBL:ACZ40944.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ40944.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ40944.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- FUNCTION: Catalyzes the condensation reaction of fatty acid
CC       synthesis by the addition to an acyl acceptor of two carbons from
CC       malonyl-ACP. {ECO:0000256|PIRNR:PIRNR000447}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-
CC         (13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP];
CC         Xref=Rhea:RHEA:14565, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC         Rhea:RHEA-COMP:9921, Rhea:RHEA-COMP:9922, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449,
CC         ChEBI:CHEBI:78778, ChEBI:CHEBI:78779; EC=2.3.1.179;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000447};
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC       {ECO:0000256|PIRNR:PIRNR000447}.
CC   -!- SIMILARITY: Belongs to the beta-ketoacyl-ACP synthases family.
CC       {ECO:0000256|PIRNR:PIRNR000447, ECO:0000256|RuleBase:RU003694,
CC       ECO:0000256|SAAS:SAAS01172730}.
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DR   EMBL; CP001825; ACZ40944.1; -; Genomic_DNA.
DR   RefSeq; WP_012873979.1; NC_013525.1.
DR   STRING; 525904.Tter_0021; -.
DR   EnsemblBacteria; ACZ40944; ACZ40944; Tter_0021.
DR   KEGG; ttr:Tter_0021; -.
DR   eggNOG; ENOG4105C0Q; Bacteria.
DR   eggNOG; COG0304; LUCA.
DR   HOGENOM; HOG000060166; -.
DR   KO; K09458; -.
DR   OMA; HADVLGW; -.
DR   OrthoDB; 606297at2; -.
DR   BioCyc; TTER525904:G1GGS-21-MONOMER; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0033817; F:beta-ketoacyl-acyl-carrier-protein synthase II activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR017568; 3-oxoacyl-ACP_synth-2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   PIRSF; PIRSF000447; KAS_II; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR03150; fabF; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CDD8.
DR   SWISS-2DPAGE; D1CDD8.
KW   Acyltransferase {ECO:0000256|PIRNR:PIRNR000447};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Fatty acid biosynthesis {ECO:0000256|PIRNR:PIRNR000447};
KW   Fatty acid metabolism {ECO:0000256|PIRNR:PIRNR000447};
KW   Lipid biosynthesis {ECO:0000256|PIRNR:PIRNR000447};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR000447};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000447,
KW   ECO:0000256|RuleBase:RU003694, ECO:0000256|SAAS:SAAS01184688}.
FT   DOMAIN        7    415       PKS_KS. {ECO:0000259|SMART:SM00825}.
FT   ACT_SITE    165    165       {ECO:0000256|PIRSR:PIRSR000447-1}.
SQ   SEQUENCE   415 AA;  43890 MW;  A7BA608E5974A0C0 CRC64;
     MKTDRRVVIT GIGAVTPIGT TRQGLWSGVC KEKSAVDRIT RFDPSQFRSQ VAAEIKDFDP
     ATYLPPKKLA RLDRFSQFSI VAAMQAVDDA GLDIDALDKD RVGIFIGSAL GGVGYAEEQH
     SIFVEKGLRA VSASLALSVF GGASSSNISM HFGITGPQLS NANSCSSGTI AIGEAFMAIR
     SGRADVILAG GAEAPLYPLT FGAFSLIKVM SARNDDPETA CRPFDRDRDG FVMGEGAAVL
     VLESLEHALR RNAQILGEII GYASTSDAYH MTAPLPTGEQ ASRCMALAIA NAGCSTDEID
     YINAHGSSTP LNDSTETLAI KKVFGERAYK IPVSATKSMH GHALGASGAI EIAICCMALA
     CDYIPATVNL ISPSDDCDLD YVPNRGRKAK VDTILSNSFG FGGINASIVI RRFET
//

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