(data stored in ACNUC7421 zone)

SWISSPROT: D1CDG6_THET1

ID   D1CDG6_THET1            Unreviewed;       811 AA.
AC   D1CDG6;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   16-JAN-2019, entry version 60.
DE   RecName: Full=Vitamin B12-dependent ribonucleotide reductase {ECO:0000256|RuleBase:RU364064};
DE            EC=1.17.4.1 {ECO:0000256|RuleBase:RU364064};
GN   OrderedLocusNames=Tter_0049 {ECO:0000313|EMBL:ACZ40972.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ40972.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ40972.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- FUNCTION: Catalyzes the reduction of ribonucleotides to
CC       deoxyribonucleotides. May function to provide a pool of
CC       deoxyribonucleotide precursors for DNA repair during oxygen
CC       limitation and/or for immediate growth after restoration of
CC       oxygen. {ECO:0000256|RuleBase:RU364064}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-
CC         diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-
CC         diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698,
CC         Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:50058, ChEBI:CHEBI:57930, ChEBI:CHEBI:73316;
CC         EC=1.17.4.1; Evidence={ECO:0000256|RuleBase:RU364064};
CC   -!- COFACTOR:
CC       Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC         Evidence={ECO:0000256|RuleBase:RU364064};
CC   -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase
CC       class-2 family. {ECO:0000256|RuleBase:RU364064}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001825; ACZ40972.1; -; Genomic_DNA.
DR   RefSeq; WP_012874007.1; NC_013525.1.
DR   STRING; 525904.Tter_0049; -.
DR   EnsemblBacteria; ACZ40972; ACZ40972; Tter_0049.
DR   KEGG; ttr:Tter_0049; -.
DR   eggNOG; ENOG4105BZH; Bacteria.
DR   eggNOG; COG0209; LUCA.
DR   HOGENOM; HOG000229277; -.
DR   KO; K00525; -.
DR   OMA; DERWRIT; -.
DR   OrthoDB; 357568at2; -.
DR   BioCyc; TTER525904:G1GGS-49-MONOMER; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd02888; RNR_II_dimer; 1.
DR   InterPro; IPR000788; RNR_lg_C.
DR   InterPro; IPR013509; RNR_lsu_N.
DR   InterPro; IPR013344; RNR_NrdJ/NrdZ.
DR   InterPro; IPR008926; RNR_R1-su_N.
DR   InterPro; IPR002645; STAS_dom.
DR   Pfam; PF02867; Ribonuc_red_lgC; 1.
DR   Pfam; PF00317; Ribonuc_red_lgN; 1.
DR   PRINTS; PR01183; RIBORDTASEM1.
DR   SUPFAM; SSF48168; SSF48168; 1.
DR   TIGRFAMs; TIGR02504; NrdJ_Z; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CDG6.
DR   SWISS-2DPAGE; D1CDG6.
KW   Cobalamin {ECO:0000256|RuleBase:RU364064};
KW   Cobalt {ECO:0000256|RuleBase:RU364064};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   DNA synthesis {ECO:0000256|RuleBase:RU364064};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU364064};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU364064};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323}.
FT   DOMAIN        1     41       STAS. {ECO:0000259|PROSITE:PS50801}.
FT   COILED       15     35       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   811 AA;  89626 MW;  0B1A49C0BA0D16B8 CRC64;
     MSGTTYIDTS SIHTIEDLER EVQALIDSGR ATKLEGYREK IFLDRYARKD PNGTPLEHYP
     EEMWLRVAKA IAAVEPNPEA QRQWTLRFYD ILQGFRFVPG GRILSGAGSG AEVTYYNCFV
     IPSPEDSVEG IFRNITTAAH IMRRSGGVGV NLSSLRPRGA YIKTVNGTSS GPCSWAILYS
     DMTGKVIIQG GSRRGALMIM LDDDHPDIEE FVEYKRKNPG HIDHANLSVA VSDAFMEAVK
     KDLPWDLKWQ GKVWKTIRAR DLWRKIAESA WAYAEPGLVF IDRYNKRSNT WYFENIRCVN
     PCGEQGLPPW GVCNLGALNL LAFVKHIDGE TYFDFEDLAN TARVAIRFLD NVIDATVYPF
     PENEEAQKHG ARRTGLGTMG LADVLIKLGV KYGSPEAEPL VERIYRTIRD AAYDASADLA
     AEKGPFPKFD RDKYMQGEFI RELPEEIQAK IRRQGIRNAV LLTQAPTGTT SSLAGVNSGI
     EPVFAFVTKR RDRLGEHLLY HPLAQEWMDA HPGKPLPDYF VSSADLTPEE HIRIQAVVQK
     YTDSSISKTV NGPEDNTVED VERLYMLAYD TGCKGITYYR QGSRDAVLEA VDTKPKEKAE
     KPEEAPKASH PEVHRSTLKK RPDVVSGYTR QIRAPEGKVN ITLNSDDEGL LEVFINLGKA
     GSDIAAMAEA LGRLISFALQ MPSPMSPNER AAEIADQLRG IGGSRSVGFG PGQVKSLPDA
     VGQALLKHLQ SEGIALSNGN GNGHADVESK ELVAVVAQNG NHGEETPESI AQKLLEKTYQ
     LTGNLCPSCG CNSLIAQEGC KKCYTCGYSE C
//

If you have problems or comments...

PBIL Back to PBIL home page