(data stored in ACNUC7421 zone)

SWISSPROT: D1CDK6_THET1

ID   D1CDK6_THET1            Unreviewed;       329 AA.
AC   D1CDK6;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   08-MAY-2019, entry version 51.
DE   RecName: Full=Pyruvate dehydrogenase E1 component subunit alpha {ECO:0000256|RuleBase:RU361139};
DE            EC=1.2.4.1 {ECO:0000256|RuleBase:RU361139};
GN   Name=pdhA {ECO:0000256|RuleBase:RU361139};
GN   OrderedLocusNames=Tter_0090 {ECO:0000313|EMBL:ACZ41012.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41012.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41012.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall
CC       conversion of pyruvate to acetyl-CoA and CO(2).
CC       {ECO:0000256|RuleBase:RU361139}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-
CC         lipoyl-L-lysine + H(+) + pyruvate = [dihydrolipoyllysine-residue
CC         acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine
CC         + CO2; Xref=Rhea:RHEA:19189, Rhea:RHEA-COMP:10480, Rhea:RHEA-
CC         COMP:10481, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:83099, ChEBI:CHEBI:83111;
CC         EC=1.2.4.1; Evidence={ECO:0000256|RuleBase:RU361139};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|RuleBase:RU361139};
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC       {ECO:0000256|RuleBase:RU361139}.
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DR   EMBL; CP001825; ACZ41012.1; -; Genomic_DNA.
DR   STRING; 525904.Tter_0090; -.
DR   EnsemblBacteria; ACZ41012; ACZ41012; Tter_0090.
DR   KEGG; ttr:Tter_0090; -.
DR   eggNOG; ENOG4107R0V; Bacteria.
DR   eggNOG; COG1071; LUCA.
DR   HOGENOM; HOG000281336; -.
DR   KO; K00161; -.
DR   OMA; RRFEDKC; -.
DR   BioCyc; TTER525904:G1GGS-90-MONOMER; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:InterPro.
DR   GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IEA:InterPro.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR017597; Pyrv_DH_E1_asu_subgrp-y.
DR   InterPro; IPR029061; THDP-binding.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
DR   TIGRFAMs; TIGR03182; PDH_E1_alph_y; 1.
PE   4: Predicted;
DR   PRODOM; D1CDK6.
DR   SWISS-2DPAGE; D1CDK6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU361139,
KW   ECO:0000313|EMBL:ACZ41012.1};
KW   Pyruvate {ECO:0000256|RuleBase:RU361139, ECO:0000313|EMBL:ACZ41012.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU361139}.
FT   DOMAIN       19    316       E1_dh. {ECO:0000259|Pfam:PF00676}.
SQ   SEQUENCE   329 AA;  37302 MW;  583257C73F34B5FD CRC64;
     MAKMETRTEN KEQLLELYRK MLLIRHFEER AAQLYTQAYI GGYCHLNVGE EATVVGALTS
     IREDDYVFTY YREHGHALTL GSDPKAVMAE LCGKVTGLSK GRGGSMHLFD KKHRLYGGYG
     IVGGHLPLAV GAAMAIEYKG EDSIVMCLFG EGATNIGAFH EALNLAKVYH LPVLFFCVNN
     QYAMGARVDE DSAVPEMWMK ACAYNMPAEK VDGMDLFAVR EVTQRMVEKV RETREPMFLE
     AITYRFRGHS MADAGRYRTQ EEVKQWMQRD PIHLTARRLE EMGVLDSELK AKIESEVEQE
     IEEATKFAIE SPDPDVSDLY KYVYTEDGE
//

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