(data stored in ACNUC7421 zone)

SWISSPROT: D1CDN2_THET1

ID   D1CDN2_THET1            Unreviewed;       474 AA.
AC   D1CDN2;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   16-JAN-2019, entry version 49.
DE   SubName: Full=Hyaluronidase {ECO:0000313|EMBL:ACZ41038.1};
GN   OrderedLocusNames=Tter_0116 {ECO:0000313|EMBL:ACZ41038.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41038.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41038.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [3] {ECO:0000213|PDB:5DIY}
RP   X-RAY CRYSTALLOGRAPHY (2.06 ANGSTROMS) IN COMPLEX WITH
RP   N-ACETYL-D-GLUCOSAMINE.
RX   PubMed=26491011; DOI=10.1074/jbc.M115.689596;
RA   Ostrowski A., Gundogdu M., Ferenbach A.T., Lebedev A.A.,
RA   van Aalten D.M.;
RT   "Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc)
RT   System in the Thermophilic Bacterium Thermobaculum terrenum.";
RL   J. Biol. Chem. 290:30291-30305(2015).
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DR   EMBL; CP001825; ACZ41038.1; -; Genomic_DNA.
DR   RefSeq; WP_012874073.1; NC_013525.1.
DR   PDB; 5DIY; X-ray; 2.06 A; A/B=1-474.
DR   PDBsum; 5DIY; -.
DR   SMR; D1CDN2; -.
DR   STRING; 525904.Tter_0116; -.
DR   CAZy; GH84; Glycoside Hydrolase Family 84.
DR   EnsemblBacteria; ACZ41038; ACZ41038; Tter_0116.
DR   KEGG; ttr:Tter_0116; -.
DR   eggNOG; ENOG4105CPE; Bacteria.
DR   eggNOG; ENOG410XPBQ; LUCA.
DR   HOGENOM; HOG000077984; -.
DR   KO; K01197; -.
DR   OMA; NYPVNDG; -.
DR   OrthoDB; 1158117at2; -.
DR   BioCyc; TTER525904:G1GGS-118-MONOMER; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   InterPro; IPR011496; Beta-N-acetylglucosaminidase.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   Pfam; PF07555; NAGidase; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   1: Evidence at protein level;
DR   PRODOM; D1CDN2.
DR   SWISS-2DPAGE; D1CDN2.
KW   3D-structure {ECO:0000213|PDB:5DIY};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323}.
FT   REGION      221    223       N-acetyl-D-glucosamine binding.
FT                                {ECO:0000213|PDB:5DIY}.
FT   COILED      135    155       {ECO:0000256|SAM:Coils}.
FT   BINDING      12     12       N-acetyl-D-glucosamine; via carbonyl
FT                                oxygen. {ECO:0000213|PDB:5DIY}.
FT   BINDING      43     43       N-acetyl-D-glucosamine. {ECO:0000213|PDB:
FT                                5DIY}.
FT   BINDING     119    119       N-acetyl-D-glucosamine. {ECO:0000213|PDB:
FT                                5DIY}.
FT   BINDING     168    168       N-acetyl-D-glucosamine. {ECO:0000213|PDB:
FT                                5DIY}.
FT   BINDING     228    228       N-acetyl-D-glucosamine. {ECO:0000213|PDB:
FT                                5DIY}.
FT   BINDING     257    257       N-acetyl-D-glucosamine. {ECO:0000213|PDB:
FT                                5DIY}.
SQ   SEQUENCE   474 AA;  55426 MW;  28B82B0654E50F71 CRC64;
     MEYFRYRGII EGFYGKPWEH QERLDMFEFM QANNLNAYIY APKQDLYHRE LWREPYKEEQ
     LQLFKELIEK AGSCGINFTF AISPGLSLVY SSEEELETLI RKITPFLEMG VHSIGIFFDD
     VPFDLIHEED RNSYSNLAEA QADFLTRVLQ RLESTISTPQ IIMCPTFYCN DPNLEYLRIL
     GQRLPKNIDV FWTGPNVCSH EITTSHMQEV QKSLQRPATL WDNYPVNDGG MMPELHIGPY
     DHRDPELHTH VVGIYANPMA LPEASKLPLY TFAQYLNSPS QYNPQDSWRQ AVSTLLGEDN
     LSAMEKFYQS NTISCLEPEE PAYLTNLFKK VQEDFASFRF EQGLRTLREE IISMQTTYSR
     LSTQDSKFFW EIRPWLEEYK LWTDYLDQAM ITFSNLFTGF FTADEEQARE SLQKALQGRT
     YLREVLKDAV DFRTRVCGDV VRNFLQQVLR STVSIELQAE GKEWTALPPG IVRD
//

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