(data stored in ACNUC7421 zone)

SWISSPROT: D1CDV9_THET1

ID   D1CDV9_THET1            Unreviewed;       532 AA.
AC   D1CDV9;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   08-MAY-2019, entry version 58.
DE   SubName: Full=2-isopropylmalate synthase/homocitrate synthase family protein {ECO:0000313|EMBL:ACZ41115.1};
GN   OrderedLocusNames=Tter_0193 {ECO:0000313|EMBL:ACZ41115.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41115.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41115.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- SIMILARITY: Belongs to the alpha-IPM synthase/homocitrate synthase
CC       family. {ECO:0000256|RuleBase:RU003523,
CC       ECO:0000256|SAAS:SAAS00580399}.
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DR   EMBL; CP001825; ACZ41115.1; -; Genomic_DNA.
DR   STRING; 525904.Tter_0193; -.
DR   EnsemblBacteria; ACZ41115; ACZ41115; Tter_0193.
DR   KEGG; ttr:Tter_0193; -.
DR   eggNOG; ENOG4105CYQ; Bacteria.
DR   eggNOG; COG0119; LUCA.
DR   HOGENOM; HOG000046860; -.
DR   KO; K01649; -.
DR   OMA; KSWDFHV; -.
DR   BioCyc; TTER525904:G1GGS-196-MONOMER; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0003852; F:2-isopropylmalate synthase activity; IEA:InterPro.
DR   GO; GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013709; 2-isopropylmalate_synth_dimer.
DR   InterPro; IPR002034; AIPM/Hcit_synth_CS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005675; Citramal_synthase.
DR   InterPro; IPR036230; LeuA_allosteric_dom_sf.
DR   InterPro; IPR000891; PYR_CT.
DR   PANTHER; PTHR43538; PTHR43538; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   Pfam; PF08502; LeuA_dimer; 1.
DR   SMART; SM00917; LeuA_dimer; 1.
DR   SUPFAM; SSF110921; SSF110921; 1.
DR   TIGRFAMs; TIGR00977; citramal_synth; 1.
DR   PROSITE; PS00815; AIPM_HOMOCIT_SYNTH_1; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CDV9.
DR   SWISS-2DPAGE; D1CDV9.
KW   Amino-acid biosynthesis {ECO:0000256|SAAS:SAAS00161459};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|SAAS:SAAS00160591}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   Transferase {ECO:0000256|RuleBase:RU003523,
KW   ECO:0000256|SAAS:SAAS00131367}.
FT   DOMAIN        4    273       Pyruvate carboxyltransferase.
FT                                {ECO:0000259|PROSITE:PS50991}.
FT   COILED      356    376       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   532 AA;  59028 MW;  1EE1D741259B7A83 CRC64;
     MRQIKIYDTT LRDGSQMEGI SFSVEDKLKL TRRLDELGVH YIEGGWPGSN PKDAEYFERM
     KNIPLKNAKL AAFGSTRRAY ASVEEDLNLR MLIEAGTPVI TLVGKSWDMQ VHVVLGCSLE
     ENLAMIKDSI AFCKSYGKEV FFDAEHFFDG YKNNPDYAMR CIHAAIEAGA DAVVLCDTNG
     GRMPEEIAQA VEKVVEETRA IAATRPFDVG IHTHNDSELA VANTLIAVQK GATQVQGTIN
     GYGERIGNAN LCSIIANLEL KYGYHTIGRE KVKELTSVSR YFAEVANMAH DERLPYVGAK
     AFTHKAGLHV NAVAKSAETY EHLPPELVGN TRRVTISELG GRSNVLMKMA QFGLEAHTSS
     EQVRQVLEEV KRLEKEGFQF EDAEASFELL VLRAQPDYEP PFRLLDFMVV SESRNGGEFL
     SEATVKIKVG NEVMHTAADG DGPVNALDRA MRKALAPFYP ELDPVHLTDY KVRVLDNESG
     TAATVRVWIQ STDGKSTWNT VGSSTNIIEA SWLALADSLE YPLRSISKRR LR
//

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