(data stored in ACNUC7421 zone)

SWISSPROT: D1CDY8_THET1

ID   D1CDY8_THET1            Unreviewed;       394 AA.
AC   D1CDY8;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   08-MAY-2019, entry version 53.
DE   RecName: Full=Zinc metalloprotease {ECO:0000256|PIRNR:PIRNR006404};
GN   OrderedLocusNames=Tter_0222 {ECO:0000313|EMBL:ACZ41144.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41144.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41144.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006404,
CC         ECO:0000256|PIRSR:PIRSR006404-2};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRNR:PIRNR006404,
CC       ECO:0000256|PIRSR:PIRSR006404-2};
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|PIRNR:PIRNR006404}; Multi-pass membrane protein
CC       {ECO:0000256|PIRNR:PIRNR006404}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|PIRNR:PIRNR006404}.
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DR   EMBL; CP001825; ACZ41144.1; -; Genomic_DNA.
DR   RefSeq; WP_012874179.1; NC_013525.1.
DR   STRING; 525904.Tter_0222; -.
DR   MEROPS; M50.006; -.
DR   EnsemblBacteria; ACZ41144; ACZ41144; Tter_0222.
DR   KEGG; ttr:Tter_0222; -.
DR   eggNOG; ENOG4106KZE; Bacteria.
DR   eggNOG; COG1994; LUCA.
DR   HOGENOM; HOG000224506; -.
DR   OMA; IELHITF; -.
DR   OrthoDB; 1401629at2; -.
DR   BioCyc; TTER525904:G1GGS-225-MONOMER; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR008915; Peptidase_M50.
DR   InterPro; IPR016483; UCP006404_Pept_M50_CBS.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   PIRSF; PIRSF006404; UCP006404_Pept_M50_CBS; 1.
DR   SMART; SM00116; CBS; 2.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
DR   PRODOM; D1CDY8.
DR   SWISS-2DPAGE; D1CDY8.
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|PIRNR:PIRNR006404};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR006404};
KW   Membrane {ECO:0000256|PIRNR:PIRNR006404};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR006404,
KW   ECO:0000256|PIRSR:PIRSR006404-2};
KW   Metalloprotease {ECO:0000256|PIRNR:PIRNR006404};
KW   Protease {ECO:0000256|PIRNR:PIRNR006404};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   Transmembrane {ECO:0000256|PIRNR:PIRNR006404};
KW   Transmembrane helix {ECO:0000256|PIRNR:PIRNR006404};
KW   Zinc {ECO:0000256|PIRNR:PIRNR006404, ECO:0000256|PIRSR:PIRSR006404-2}.
FT   TRANSMEM     21     42       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   TRANSMEM     48     67       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   TRANSMEM    108    136       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   TRANSMEM    156    176       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   TRANSMEM    197    222       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   TRANSMEM    228    246       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   DOMAIN      272    328       CBS. {ECO:0000259|PROSITE:PS51371}.
FT   DOMAIN      335    394       CBS. {ECO:0000259|PROSITE:PS51371}.
FT   ACT_SITE     69     69       {ECO:0000256|PIRSR:PIRSR006404-1}.
FT   METAL        68     68       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR006404-2}.
FT   METAL        72     72       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR006404-2}.
FT   METAL       179    179       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR006404-2}.
SQ   SEQUENCE   394 AA;  43381 MW;  0C0C471F364409D4 CRC64;
     MLGPGIPIGR IFGIRIYIDP SWIFIFLLVT WNLAAGALAV VHPEWGTTTI WLVAIAASLL
     FFGSVLAHEL AHSLVARSQG VPVRRITLFM FGGVADIERE PPSPRAEFLI TVVGPLTSLV
     LGIVFLVIGT AIAGISNLSI YNPEGLLAQL NPLSTIFLWL GPINIVLAVF NLVPGFPLDG
     GRILRSIIWA ISNNLRLATR IASFIGQAIG WLMILAGVAM IFGAHIPFFG TGLVSGLWLI
     FIGWFLSSAA SQSYRQLVIH HILEGVPVNR IMRTDIPTAS PYMTIEDLVR LLLINSDERS
     FPVVEEDRLV GLVCIEDLKK VAREEWPIVP VSRIMTPRDK LITIGPNDDL AKAFEQLARI
     DVNQLPVVVG DTLVGLLRRR DLLRWLQIHS QIAR
//

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