(data stored in ACNUC7421 zone)

SWISSPROT: D1CE24_THET1

ID   D1CE24_THET1            Unreviewed;       573 AA.
AC   D1CE24;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   16-JAN-2019, entry version 65.
DE   SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:ACZ41180.1};
GN   OrderedLocusNames=Tter_0258 {ECO:0000313|EMBL:ACZ41180.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41180.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41180.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2
CC       (CPA2) transporter (TC 2.A.37) family.
CC       {ECO:0000256|SAAS:SAAS01092086}.
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DR   EMBL; CP001825; ACZ41180.1; -; Genomic_DNA.
DR   RefSeq; WP_012874215.1; NC_013525.1.
DR   STRING; 525904.Tter_0258; -.
DR   EnsemblBacteria; ACZ41180; ACZ41180; Tter_0258.
DR   KEGG; ttr:Tter_0258; -.
DR   eggNOG; ENOG4105CKD; Bacteria.
DR   eggNOG; COG1226; LUCA.
DR   eggNOG; COG4651; LUCA.
DR   HOGENOM; HOG000179078; -.
DR   KO; K03455; -.
DR   OMA; HVGVSMA; -.
DR   OrthoDB; 941006at2; -.
DR   BioCyc; TTER525904:G1GGS-262-MONOMER; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02254; TrkA_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51201; RCK_N; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CE24.
DR   SWISS-2DPAGE; D1CE24.
KW   Antiport {ECO:0000256|SAAS:SAAS01092098};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Ion transport {ECO:0000256|SAAS:SAAS01092081};
KW   Membrane {ECO:0000256|SAAS:SAAS01092093, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01092090,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01092105,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS01092095}.
FT   TRANSMEM      6     25       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     32     49       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     55     75       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     87    109       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    115    135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    147    167       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    187    205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    217    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    295    319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    325    344       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    356    374       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      411    533       RCK N-terminal. {ECO:0000259|PROSITE:
FT                                PS51201}.
SQ   SEQUENCE   573 AA;  61109 MW;  8E43FC6F93BF45A0 CRC64;
     MHEADLLTNL VLALSVAAIG GLVSTALKQS PIIGYLLAGI IIGPFTPGPV SNVEIISQLA
     DIGVIFLMFA VGVHISIKEI LSYGKLVLIG APLQVLAVIL IAMAIGRLIR MDTGTSLVLG
     FVVAISSSVV ISKVLEDSGE GSTDHGGIAL AWGAIQDIVT IIMVAVMPLF SSVGTDNNSV
     LLSMVKTFGF LVIAFGGGFF VLPWFMNRLA LLRNREVLLL ATAAVALIAA VGASMFGLSV
     ALGAFVAGLI VSESEISHQI LGDIVPIRDV FSALFFVSIG MLLDPRMIIS DWHLVVLGLV
     LILIVKSLIS TGIMLAMGYA IKTSVLVGLL LAQCAEFSFL LASIGRDLEL LSENSFRLML
     ATTTISVIIN PFIYRLRAPI VSFVNNLISA NNIPQPTQYA TPDIDLPDRR HAVLCGYGRV
     GAVVGAALRR RGFPFVVIEE DPRIIKELRR RGIPAIIGNA ANMSVLSAAN VESARILIIA
     ISDAVATRIA VENAKALNPN IDIVARAQSA KERDYLRHRR VSHVVLGEME LALEITRFTL
     HRFGVSGGEV QAILQGLRER SEAELGSGSL YDL
//

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