(data stored in ACNUC7421 zone)

SWISSPROT: D1CE86_THET1

ID   D1CE86_THET1            Unreviewed;       264 AA.
AC   D1CE86;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   08-MAY-2019, entry version 65.
DE   RecName: Full=Putative [LysW]-aminoadipate kinase {ECO:0000256|HAMAP-Rule:MF_02082};
DE            EC=2.7.2.- {ECO:0000256|HAMAP-Rule:MF_02082};
GN   Name=lysZ {ECO:0000256|HAMAP-Rule:MF_02082};
GN   OrderedLocusNames=Tter_0320 {ECO:0000313|EMBL:ACZ41242.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41242.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41242.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- FUNCTION: Catalyzes the phosphorylation of LysW-gamma-alpha-
CC       aminoadipate. {ECO:0000256|HAMAP-Rule:MF_02082}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[2-aminoadipate-carrier protein]-C-terminal-gamma-(L-2-
CC         aminoadip-2-yl)-L-glutamate + ATP = [2-aminoadipate-carrier
CC         protein]-C-terminal-gamma-(6-phospho-L-2-aminoadip-2-yl)-L-
CC         glutamate + ADP; Xref=Rhea:RHEA:41944, Rhea:RHEA-COMP:9694,
CC         Rhea:RHEA-COMP:9712, ChEBI:CHEBI:30616, ChEBI:CHEBI:78499,
CC         ChEBI:CHEBI:78503, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_02082};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA
CC       pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step
CC       2/5. {ECO:0000256|HAMAP-Rule:MF_02082}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02082}.
CC   -!- SIMILARITY: Belongs to the acetylglutamate kinase family. LysZ
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_02082}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_02082}.
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DR   EMBL; CP001825; ACZ41242.1; -; Genomic_DNA.
DR   RefSeq; WP_012874277.1; NC_013525.1.
DR   STRING; 525904.Tter_0320; -.
DR   EnsemblBacteria; ACZ41242; ACZ41242; Tter_0320.
DR   KEGG; ttr:Tter_0320; -.
DR   eggNOG; ENOG4107U4Q; Bacteria.
DR   eggNOG; COG0548; LUCA.
DR   HOGENOM; HOG000233259; -.
DR   KO; K05828; -.
DR   OMA; EMVYCGK; -.
DR   OrthoDB; 901370at2; -.
DR   BioCyc; TTER525904:G1GGS-324-MONOMER; -.
DR   UniPathway; UPA00033; UER00036.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   HAMAP; MF_02082; LysZ; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR004662; AcgluKinase_fam.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR001057; Glu/AcGlu_kinase.
DR   InterPro; IPR037529; LysZ.
DR   Pfam; PF00696; AA_kinase; 1.
DR   PIRSF; PIRSF000728; NAGK; 1.
DR   PRINTS; PR00474; GLU5KINASE.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00761; argB; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CE86.
DR   SWISS-2DPAGE; D1CE86.
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_02082,
KW   ECO:0000256|SAAS:SAAS01090837};
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_02082,
KW   ECO:0000256|SAAS:SAAS00088659};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02082};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_02082,
KW   ECO:0000256|SAAS:SAAS00461199, ECO:0000313|EMBL:ACZ41242.1};
KW   Lysine biosynthesis {ECO:0000256|HAMAP-Rule:MF_02082};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_02082,
KW   ECO:0000256|SAAS:SAAS00461200};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_02082,
KW   ECO:0000256|SAAS:SAAS00461129}.
FT   DOMAIN        2    242       AA_kinase. {ECO:0000259|Pfam:PF00696}.
FT   BINDING      61     61       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_02082}.
FT   BINDING     165    165       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_02082}.
FT   SITE          5      5       Transition state stabilizer.
FT                                {ECO:0000256|HAMAP-Rule:MF_02082}.
FT   SITE        226    226       Transition state stabilizer.
FT                                {ECO:0000256|HAMAP-Rule:MF_02082}.
SQ   SEQUENCE   264 AA;  28510 MW;  1833AFF6291E173C CRC64;
     MLVIKIGGSK GINVDKILED VPNIQDKMVI VHGANYELNQ VSEQLGHPPR IVTSSTGQVS
     RFTDRRTMEI FMMVYCGKVN KTIVEKLQRL GVNAVGLSAL DGGIAKGRRK DQIRVIEDGK
     PKVLRGDYAG SIQQIDTRLI NLLLDNGYLP VLTPPAISHE GEAINVDGDK LAMEIAAALH
     ADKFLIFSDT PGLLRNLEDE NSLITRVGPD EIEEAMQVAE GRAKKKVLAA GEALKRGIGQ
     VIFADGRVDA PIQKALSGIG TVIG
//

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