(data stored in ACNUC7421 zone)

SWISSPROT: D1CER8_THET1

ID   D1CER8_THET1            Unreviewed;       242 AA.
AC   D1CER8;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   08-MAY-2019, entry version 65.
DE   RecName: Full=Demethylmenaquinone methyltransferase {ECO:0000256|HAMAP-Rule:MF_01813};
DE            EC=2.1.1.163 {ECO:0000256|HAMAP-Rule:MF_01813};
GN   Name=menG {ECO:0000256|HAMAP-Rule:MF_01813};
GN   OrderedLocusNames=Tter_0503 {ECO:0000313|EMBL:ACZ41424.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41424.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41424.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- FUNCTION: Methyltransferase required for the conversion of
CC       demethylmenaquinol (DMKH2) to menaquinol (MKH2).
CC       {ECO:0000256|HAMAP-Rule:MF_01813}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a
CC         menaquinol + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42640, Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:18151, ChEBI:CHEBI:55437,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.163;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01813};
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis;
CC       menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.
CC       {ECO:0000256|HAMAP-Rule:MF_01813}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. MenG/UbiE family.
CC       {ECO:0000256|HAMAP-Rule:MF_01813, ECO:0000256|SAAS:SAAS00572359}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01813}.
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DR   EMBL; CP001825; ACZ41424.1; -; Genomic_DNA.
DR   RefSeq; WP_012874459.1; NC_013525.1.
DR   STRING; 525904.Tter_0503; -.
DR   EnsemblBacteria; ACZ41424; ACZ41424; Tter_0503.
DR   KEGG; ttr:Tter_0503; -.
DR   eggNOG; ENOG4105DDZ; Bacteria.
DR   eggNOG; COG2226; LUCA.
DR   HOGENOM; HOG000249463; -.
DR   KO; K03183; -.
DR   OMA; VRNFENL; -.
DR   OrthoDB; 1431378at2; -.
DR   BioCyc; TTER525904:G1GGS-507-MONOMER; -.
DR   UniPathway; UPA00079; UER00169.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0102955; F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01813; MenG_UbiE_methyltr; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR   InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR   Pfam; PF01209; Ubie_methyltran; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR   PROSITE; PS51608; SAM_MT_UBIE; 1.
DR   PROSITE; PS01183; UBIE_1; 1.
DR   PROSITE; PS01184; UBIE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CER8.
DR   SWISS-2DPAGE; D1CER8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Menaquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_01813};
KW   Methyltransferase {ECO:0000256|HAMAP-Rule:MF_01813,
KW   ECO:0000256|SAAS:SAAS00092033, ECO:0000313|EMBL:ACZ41424.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_01813,
KW   ECO:0000256|SAAS:SAAS00463460};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_01813,
KW   ECO:0000256|SAAS:SAAS00463451, ECO:0000313|EMBL:ACZ41424.1};
KW   Ubiquinone {ECO:0000313|EMBL:ACZ41424.1}.
FT   REGION      114    115       S-adenosyl-L-methionine binding.
FT                                {ECO:0000256|HAMAP-Rule:MF_01813}.
FT   BINDING      65     65       S-adenosyl-L-methionine.
FT                                {ECO:0000256|HAMAP-Rule:MF_01813}.
FT   BINDING      86     86       S-adenosyl-L-methionine.
FT                                {ECO:0000256|HAMAP-Rule:MF_01813}.
SQ   SEQUENCE   242 AA;  26701 MW;  1527F7C8732844CB CRC64;
     MKTRYLPPPE QKAQYVREMF TSIAPVYDRL NSIISLGLHR LWRRTAVRLS GLKPGDSALD
     VATGTGDFAI TLAKAVGPTG RVVGIDFSEG MLRLAHEKIK RLGLDGVIQF EWADALSLPF
     ADGEFDAATV GFAGRNVTDL KGMFSEMRRV VRPGGRVVHL ELSRPTLPIF RDIYRIYFYH
     LVPVVGGALA RSRSAYGYLP ESLSVFPSPE EVARVMREAG LVKVRYYPLA LGTVTVHVGV
     VP
//

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