(data stored in ACNUC7421 zone)

SWISSPROT: D1CEW6_THET1

ID   D1CEW6_THET1            Unreviewed;       403 AA.
AC   D1CEW6;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   08-MAY-2019, entry version 71.
DE   RecName: Full=Galactokinase {ECO:0000256|HAMAP-Rule:MF_00246, ECO:0000256|SAAS:SAAS00080100};
DE            EC=2.7.1.6 {ECO:0000256|HAMAP-Rule:MF_00246, ECO:0000256|SAAS:SAAS00015833};
DE   AltName: Full=Galactose kinase {ECO:0000256|HAMAP-Rule:MF_00246};
GN   Name=galK {ECO:0000256|HAMAP-Rule:MF_00246};
GN   OrderedLocusNames=Tter_0554 {ECO:0000313|EMBL:ACZ41472.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41472.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41472.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- FUNCTION: Catalyzes the transfer of the gamma-phosphate of ATP to
CC       D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
CC       {ECO:0000256|HAMAP-Rule:MF_00246, ECO:0000256|SAAS:SAAS00541114}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-
CC         phosphate + H(+); Xref=Rhea:RHEA:13553, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:28061, ChEBI:CHEBI:30616, ChEBI:CHEBI:58336,
CC         ChEBI:CHEBI:456216; EC=2.7.1.6; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00246, ECO:0000256|SAAS:SAAS01118323};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000256|HAMAP-Rule:MF_00246, ECO:0000256|SAAS:SAAS00015843}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00246,
CC       ECO:0000256|SAAS:SAAS00345504}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00246, ECO:0000256|SAAS:SAAS00544826}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00246}.
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DR   EMBL; CP001825; ACZ41472.1; -; Genomic_DNA.
DR   RefSeq; WP_012874507.1; NC_013525.1.
DR   STRING; 525904.Tter_0554; -.
DR   EnsemblBacteria; ACZ41472; ACZ41472; Tter_0554.
DR   KEGG; ttr:Tter_0554; -.
DR   eggNOG; ENOG4105CRD; Bacteria.
DR   eggNOG; COG0153; LUCA.
DR   HOGENOM; HOG000241101; -.
DR   KO; K00849; -.
DR   OMA; YECSHPD; -.
DR   OrthoDB; 1388391at2; -.
DR   BioCyc; TTER525904:G1GGS-558-MONOMER; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004335; F:galactokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005534; F:galactose binding; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.890; -; 1.
DR   HAMAP; MF_00246; Galactokinase; 1.
DR   InterPro; IPR000705; Galactokinase.
DR   InterPro; IPR022963; Galactokinase_bac.
DR   InterPro; IPR019741; Galactokinase_CS.
DR   InterPro; IPR019539; GalKase_gal-bd.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR036554; GHMP_kinase_C_sf.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR   InterPro; IPR006206; Mevalonate/galactokinase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10457:SF6; PTHR10457:SF6; 1.
DR   Pfam; PF10509; GalKase_gal_bdg; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000530; Galactokinase; 1.
DR   PRINTS; PR00473; GALCTOKINASE.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55060; SSF55060; 1.
DR   TIGRFAMs; TIGR00131; gal_kin; 1.
DR   PROSITE; PS00106; GALACTOKINASE; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CEW6.
DR   SWISS-2DPAGE; D1CEW6.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00246,
KW   ECO:0000256|SAAS:SAAS00456406};
KW   Carbohydrate metabolism {ECO:0000256|HAMAP-Rule:MF_00246,
KW   ECO:0000256|SAAS:SAAS00132170};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00246,
KW   ECO:0000256|SAAS:SAAS00423689};
KW   Galactose metabolism {ECO:0000256|HAMAP-Rule:MF_00246,
KW   ECO:0000256|SAAS:SAAS00132176};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00246,
KW   ECO:0000256|SAAS:SAAS00456396, ECO:0000313|EMBL:ACZ41472.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00246,
KW   ECO:0000256|SAAS:SAAS00423699};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00246,
KW   ECO:0000256|SAAS:SAAS00423702};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00246,
KW   ECO:0000256|SAAS:SAAS00456300};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00246,
KW   ECO:0000256|SAAS:SAAS00456450}.
FT   DOMAIN       16     64       GalKase_gal_bdg. {ECO:0000259|Pfam:
FT                                PF10509}.
FT   DOMAIN      122    184       GHMP_kinases_N. {ECO:0000259|Pfam:
FT                                PF00288}.
FT   DOMAIN      287    367       GHMP_kinases_C. {ECO:0000259|Pfam:
FT                                PF08544}.
FT   NP_BIND     127    133       ATP. {ECO:0000256|HAMAP-Rule:MF_00246}.
FT   REGION       40     43       Substrate binding. {ECO:0000256|HAMAP-
FT                                Rule:MF_00246}.
FT   ACT_SITE    177    177       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00246}.
FT   METAL       133    133       Magnesium. {ECO:0000256|HAMAP-Rule:
FT                                MF_00246}.
FT   METAL       165    165       Magnesium. {ECO:0000256|HAMAP-Rule:
FT                                MF_00246}.
FT   BINDING     227    227       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00246}.
FT   SITE         34     34       Transition state stabilizer.
FT                                {ECO:0000256|HAMAP-Rule:MF_00246}.
SQ   SEQUENCE   403 AA;  44923 MW;  83C02A7920744192 CRC64;
     MTEEYRFKHI GALIRAFEMR YGGKPTIASR APGRINLIGE HTDYNDGWVL PAAINYEINV
     VCRPRNDSLV RLVALDMGKE SDFYLENHNR TDFLWLRYPQ GVAVELQNRG YKLRGMEAVY
     MGDIPVGSGL SSSAAVEVAF VHAFCRAADI ELSGEEVALI AQRAENDFVG VPCGVMDQFV
     SSLGRQDHAL LLDSRSLEYQ HIPINLPNVS LVILDTGVSR ELAGSEYKKR RQDCEEAVTR
     LSTRISGIKA LRDVTLEQLE ENLDLLTSTQ RKRARHVIEE NMRTLEAAEA LRNGDAAAIG
     RLMKESHISL RDLYEVSSFE LDTIVEIAWD TDGVIGARMT GAGFGGVALA LVHQDAVPTL
     YERVMQEYHA RTGKEPKVFV CRAVDGAESA LMEEVQVHSI WNV
//

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