(data stored in ACNUC7421 zone)

SWISSPROT: D1CEW7_THET1

ID   D1CEW7_THET1            Unreviewed;       329 AA.
AC   D1CEW7;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   08-MAY-2019, entry version 62.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000256|RuleBase:RU000506};
DE            EC=2.7.7.12 {ECO:0000256|RuleBase:RU000506};
GN   OrderedLocusNames=Tter_0555 {ECO:0000313|EMBL:ACZ41473.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41473.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41473.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose =
CC         alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:13989, ChEBI:CHEBI:58336, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885, ChEBI:CHEBI:66914; EC=2.7.7.12;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU10033,
CC         ECO:0000256|RuleBase:RU000506};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000808-3};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR000808-
CC       3};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000256|RuleBase:RU000506}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate
CC       uridylyltransferase type 1 family.
CC       {ECO:0000256|RuleBase:RU000506}.
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DR   EMBL; CP001825; ACZ41473.1; -; Genomic_DNA.
DR   RefSeq; WP_012874508.1; NC_013525.1.
DR   STRING; 525904.Tter_0555; -.
DR   EnsemblBacteria; ACZ41473; ACZ41473; Tter_0555.
DR   KEGG; ttr:Tter_0555; -.
DR   eggNOG; ENOG4105F0Z; Bacteria.
DR   eggNOG; COG1085; LUCA.
DR   HOGENOM; HOG000230489; -.
DR   KO; K00965; -.
DR   OMA; QIWANEQ; -.
DR   OrthoDB; 1064872at2; -.
DR   BioCyc; TTER525904:G1GGS-559-MONOMER; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0033499; P:galactose catabolic process via UDP-galactose; IEA:InterPro.
DR   CDD; cd00608; GalT; 1.
DR   Gene3D; 3.30.428.10; -; 2.
DR   InterPro; IPR001937; GalP_UDPtransf1.
DR   InterPro; IPR019779; GalP_UDPtransf1_His-AS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR11943; PTHR11943; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF000808; GalT; 1.
DR   SUPFAM; SSF54197; SSF54197; 2.
DR   TIGRFAMs; TIGR00209; galT_1; 1.
DR   PROSITE; PS00117; GAL_P_UDP_TRANSF_I; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CEW7.
DR   SWISS-2DPAGE; D1CEW7.
KW   Carbohydrate metabolism {ECO:0000256|RuleBase:RU000506};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Galactose metabolism {ECO:0000256|RuleBase:RU000506};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000808-3,
KW   ECO:0000256|RuleBase:RU000506};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000506,
KW   ECO:0000313|EMBL:ACZ41473.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   Transferase {ECO:0000256|RuleBase:RU000506,
KW   ECO:0000313|EMBL:ACZ41473.1}; Zinc {ECO:0000256|PIRSR:PIRSR000808-3}.
FT   DOMAIN        2    159       GalP_UDP_transf. {ECO:0000259|Pfam:
FT                                PF01087}.
FT   DOMAIN      174    319       GalP_UDP_tr_C. {ECO:0000259|Pfam:
FT                                PF02744}.
FT   ACT_SITE    149    149       Tele-UMP-histidine intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR000808-1,
FT                                ECO:0000256|PROSITE-ProRule:PRU10033}.
FT   METAL        32     32       Zinc. {ECO:0000256|PIRSR:PIRSR000808-3}.
FT   METAL        35     35       Zinc. {ECO:0000256|PIRSR:PIRSR000808-3}.
FT   METAL        96     96       Zinc. {ECO:0000256|PIRSR:PIRSR000808-3}.
FT   METAL       147    147       Zinc. {ECO:0000256|PIRSR:PIRSR000808-3,
FT                                ECO:0000256|PROSITE-ProRule:PRU10033}.
SQ   SEQUENCE   329 AA;  38174 MW;  F528B6B1DDCA9C07 CRC64;
     MSELRWHPLL REWVITATHR QDRTFLPPRD YCPLCPTKSG KHETEIPVET FDIAVFENKF
     PSLQRQPPQP AIEPMGIFDV RPAEGVCEVV VYTPEHDTTL TDQSVSHIRR LIAVWRDRYI
     ELGSLPYVKY VFIFENKGEV IGVTLHHPHG QIYAYPFIPP LMQRELSALS EHRAKTGRCL
     VCDVLQQETN YGKRILFEEG NFVAFIPFYA RWPYEVHIIP RRHFGSLAEI TSEESWDLAY
     ALKRVLVGYD KLFGFSMPFI MALHQTPTDD QEHPYYHFQL QFYPPHRTST KLKYLAGSET
     GAGTFINDSL PEEKAPELRA VIPDKESIE
//

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