(data stored in ACNUC7421 zone)

SWISSPROT: D3EYQ5_CONWI

ID   D3EYQ5_CONWI            Unreviewed;       369 AA.
AC   D3EYQ5;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   07-JUN-2017, entry version 45.
DE   RecName: Full=DNA polymerase III subunit beta {ECO:0000256|PIRNR:PIRNR000804, ECO:0000256|SAAS:SAAS00729347};
DE            EC=2.7.7.7 {ECO:0000256|PIRNR:PIRNR000804, ECO:0000256|SAAS:SAAS00729426};
GN   OrderedLocusNames=Cwoe_0002 {ECO:0000313|EMBL:ADB48438.1};
OS   Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 /
OS   ID131577).
OC   Bacteria; Actinobacteria; Thermoleophilia; Solirubrobacterales;
OC   Conexibacteraceae; Conexibacter.
OX   NCBI_TaxID=469383 {ECO:0000313|EMBL:ADB48438.1, ECO:0000313|Proteomes:UP000008229};
RN   [1] {ECO:0000313|Proteomes:UP000008229}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14684 / JCM 11494 / NBRC 100937 / ID131577
RC   {ECO:0000313|Proteomes:UP000008229};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA   Hugenholtz P., Woyke T., Wu D., Pukall R., Steenblock K.,
RA   Schneider S., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Conexibacter woesei DSM 14684.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria.
CC       This DNA polymerase also exhibits 3' to 5' exonuclease activity.
CC       The beta chain is required for initiation of replication once it
CC       is clamped onto DNA, it slides freely (bidirectional and ATP-
CC       independent) along duplex DNA. {ECO:0000256|PIRNR:PIRNR000804}.
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1). {ECO:0000256|PIRNR:PIRNR000804,
CC       ECO:0000256|SAAS:SAAS00729508}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR000804,
CC       ECO:0000256|SAAS:SAAS00729396}.
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DR   EMBL; CP001854; ADB48438.1; -; Genomic_DNA.
DR   RefSeq; WP_012931491.1; NC_013739.1.
DR   ProteinModelPortal; D3EYQ5; -.
DR   STRING; 469383.Cwoe_0002; -.
DR   EnsemblBacteria; ADB48438; ADB48438; Cwoe_0002.
DR   KEGG; cwo:Cwoe_0002; -.
DR   eggNOG; ENOG4105CZ8; Bacteria.
DR   eggNOG; COG0592; LUCA.
DR   HOGENOM; HOG000071793; -.
DR   KO; K02338; -.
DR   OMA; VCGLNGH; -.
DR   OrthoDB; POG091H02B3; -.
DR   BioCyc; CWOE469383:GH82-2-MONOMER; -.
DR   Proteomes; UP000008229; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00140; beta_clamp; 1.
DR   InterPro; IPR001001; DNA_polIII_beta.
DR   InterPro; IPR022635; DNA_polIII_beta_C.
DR   InterPro; IPR022637; DNA_polIII_beta_cen.
DR   InterPro; IPR022634; DNA_polIII_beta_N.
DR   PANTHER; PTHR30478:SF1; PTHR30478:SF1; 1.
DR   Pfam; PF00712; DNA_pol3_beta; 1.
DR   Pfam; PF02767; DNA_pol3_beta_2; 1.
DR   Pfam; PF02768; DNA_pol3_beta_3; 1.
DR   PIRSF; PIRSF000804; DNA_pol_III_b; 1.
DR   SMART; SM00480; POL3Bc; 1.
DR   TIGRFAMs; TIGR00663; dnan; 1.
PE   4: Predicted;
DR   PRODOM; D3EYQ5.
DR   SWISS-2DPAGE; D3EYQ5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008229};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR000804,
KW   ECO:0000256|SAAS:SAAS00729481};
KW   DNA replication {ECO:0000256|PIRNR:PIRNR000804,
KW   ECO:0000256|SAAS:SAAS00729460};
KW   DNA-directed DNA polymerase {ECO:0000256|PIRNR:PIRNR000804,
KW   ECO:0000256|SAAS:SAAS00729479};
KW   Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000804,
KW   ECO:0000256|SAAS:SAAS00729386, ECO:0000313|EMBL:ADB48438.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008229};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000804,
KW   ECO:0000256|SAAS:SAAS00729371, ECO:0000313|EMBL:ADB48438.1}.
FT   DOMAIN        1    118       DNA_pol3_beta. {ECO:0000259|Pfam:
FT                                PF00712}.
FT   DOMAIN      130    245       DNA_pol3_beta_2. {ECO:0000259|Pfam:
FT                                PF02767}.
FT   DOMAIN      247    366       DNA_pol3_beta_3. {ECO:0000259|Pfam:
FT                                PF02768}.
SQ   SEQUENCE   369 AA;  40047 MW;  973C99995EA686EC CRC64;
     MKISAAREEL LAQLQTVSRV ASTRGAIQAL SGVQLIAAGG RVELRATDME VGLRVPLPAE
     IEREGSVVLP ARLIVDVVRS LSGPTATLEL RPAEQDVELV AGNAQFHIRT LRAEDFPPFP
     EPESEGVVSV PAKAFVETVL RVANSASRDE TRPVLTGIMV SASERELRMV ATDSYRLSVK
     ETTLEEPLVG GFEANVPARA LQELARLVQQ IDGEQLSVGV RQNQVVFQIG EVVLSSRLIE
     GQFPNYRQLL PDSYEHELTI TGSEVTDVVR RISLLAQKNA PLRLSFAPGE LTVSAQTPDI
     GEARESLPVA FQGEPFEIGF NPDFLRDGLE SVGSGDVMLK LISPLRPGLI QSAEDGGFLY
     LIMPIRLNV
//

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