(data stored in SCRATCH3701 zone)

SWISSPROT: D5E8V8_METMS

ID   D5E8V8_METMS            Unreviewed;       460 AA.
AC   D5E8V8;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 49.
DE   SubName: Full=Mannose-1-phosphate guanylyltransferase (GDP) mannose-6-phosphate isomerase, type 2 {ECO:0000313|EMBL:ADE35617.1};
DE            EC=2.7.7.13 {ECO:0000313|EMBL:ADE35617.1};
DE            EC=2.7.7.22 {ECO:0000313|EMBL:ADE35617.1};
DE            EC=5.3.1.8 {ECO:0000313|EMBL:ADE35617.1};
GN   OrderedLocusNames=Mmah_0081 {ECO:0000313|EMBL:ADE35617.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE35617.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE35617.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC       {ECO:0000256|RuleBase:RU004190}.
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DR   EMBL; CP001994; ADE35617.1; -; Genomic_DNA.
DR   EnsemblBacteria; ADE35617; ADE35617; Mmah_0081.
DR   KEGG; mmh:Mmah_0081; -.
DR   eggNOG; arCOG02427; Archaea.
DR   eggNOG; COG0836; LUCA.
DR   HOGENOM; HOG000153549; -.
DR   KO; K16011; -.
DR   OMA; LIVCNEK; -.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0008928; F:mannose-1-phosphate guanylyltransferase (GDP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   Gene3D; 2.60.120.10; -; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR   InterPro; IPR001538; Man6P_isomerase-2_C.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   Pfam; PF01050; MannoseP_isomer; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01479; GMP_PMI; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5E8V8.
DR   SWISS-2DPAGE; D5E8V8.
KW   Isomerase {ECO:0000313|EMBL:ADE35617.1};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:ADE35617.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059};
KW   Transferase {ECO:0000313|EMBL:ADE35617.1}.
FT   DOMAIN          6..274
FT                   /note="NTP_transferase"
FT                   /evidence="ECO:0000259|Pfam:PF00483"
FT   DOMAIN          306..455
FT                   /note="MannoseP_isomer"
FT                   /evidence="ECO:0000259|Pfam:PF01050"
SQ   SEQUENCE   460 AA;  52336 MW;  07A1AB082D9782FF CRC64;
     MVNNMKSIIL AGGSGTRLWP LSREHYPKQF LKIGEYSLFQ QTFLRCSEVS DVSEIFVVTN
     EDQKFYVIGQ IQELGYDYPK ENVLIEPEGK NTLPAICFGM KEIQERFGES NAGIFSSDHV
     LDSRAMQTIS EAKSLASRGY LLTFGIKPTS PNTGYGYIKP AENLGIGQKV SEFREKPDEE
     TARRYIEESC LWNSGMFLFN TETFFSELAQ CAPDIYESFE QNEDINQIYA ELPSISVDYG
     VMEKSQKVAV VPLQYKWSDL GNFAALYDEL DKDSDENVVY DCELLPLDSR QNLVHSRNGK
     LVSLIDVNDM IVVDTPDALL ISPKESSQKV KQIVNQLKEK NDPRAKIGQT VYRPWGSYTV
     LESSDNHVIK KIVVMPEQKL SLQLHYHRSE HWVVVTGMAE VHVNGDDYFV RPGESTFIRA
     GERHRLGNPS KIPLEIIEVQ LGEYVAEDDI VRFDDVYGRQ
//

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